Trends in prostatic adenocarcinoma tumor volume by visual estimation in prostatectomy specimens

Ian F. Green, Amy D. Black, Praveen R. Anchala, William J. Catelona, Nikolay D. Dimov, Ximing J. Yang, Debra L. Zynger

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Abstract

We retrospectively reviewed 1792 consecutive radical prostatectomies (RP) from 2003 to 2006 at a single institution to establish tumor volume reference values, to determine current trends in visually estimated prostate adenocarcinoma tumor volume, and to characterize cases with no residual cancer on RP. Tumor volumes were recorded and subsequently stratified as very low, 0-1%; low, 1.1-10%; intermediate, 10.1-20%; high, 20.1-50%; and very high, >50%, with incidences of 11.7%, 52.1%, 21.5%, 13.2%, and 1.5%, respectively. The incidence of very low volume tumors increased within the time period (p= 0.04). Seminal vesicle involvement was detected in 5.0% of cases and lymph node metastasis occurred in 1.4%. Volume categories statistically correlated with seminal vesicle invasion (p= 0) and lymph nodes metastases (p= 0). Eleven cases of no residual cancer (0.6%) were identified with a non-statically significant increase during the study (p= 0.07). The rising incidence of very low volume tumors should be considered by clinicians when discussing treatment options with patients. A discrete tumor volume should be provided for RP specimens as it may be an important prognostic factor.

Original languageEnglish
Pages (from-to)578-583
Number of pages6
JournalPathology Research and Practice
Volume208
Issue number10
DOIs
StatePublished - Oct 15 2012
Externally publishedYes

Keywords

  • Minimal residual cancer
  • Prostate cancer
  • Radical prostatectomy
  • Tumor volume
  • Vanishing cancer

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    Green, I. F., Black, A. D., Anchala, P. R., Catelona, W. J., Dimov, N. D., Yang, X. J., & Zynger, D. L. (2012). Trends in prostatic adenocarcinoma tumor volume by visual estimation in prostatectomy specimens. Pathology Research and Practice, 208(10), 578-583. https://doi.org/10.1016/j.prp.2012.06.006