Trends in pharmaceutical targeting of clinical indications: 1930-2013

Michael S. Kinch, Janie Merkel, Sheila Umlauf

Research output: Contribution to journalShort survey

21 Scopus citations

Abstract

An analysis of FDA-approved new molecular entities (NMEs) reveals trends in therapeutic applications. Four groupings (infectious diseases, cardiovascular diseases, autoimmune/inflammatory diseases and cancer) capture more than 60% of NMEs. Infectious diseases are the most targeted indications. Near the turn of the new millennium, the rate of new approvals for infectious diseases decreased. The absolute and relative number of NMEs targeting psychiatric, neurological and pain/itch indications also declined. By contrast, NMEs targeting cancer have risen in the past two decades as have NMEs targeting orphan indications. These results suggest the drug development community has largely been responsive to public health and market needs. However, finite resources might indicate emphasis on some unmet needs could come at the cost of others.

Original languageEnglish
Pages (from-to)1682-1685
Number of pages4
JournalDrug Discovery Today
Volume19
Issue number11
DOIs
StatePublished - Nov 2014
Externally publishedYes

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