Trending: Radioactive and fluorescent bimodal/hybrid tracers as multiplexing solutions for surgical guidance

Fijs W.B. van Leeuwen, Margret Schottelius, Oscar R. Brouwer, Sergi Vidal-Sicart, Samuel Achilefu, Joachim Klode, Hans Jurgen Wester, Tessa Buckle

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

By contributing to noninvasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade, it has also become apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help to empower fluorescence-guided surgery. More specifically, when using hybrid tracers, lesions can be noninvasively identified and localized with a high sensitivity and precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fluorescent dye). This topical review discusses early clinical successes, preclinical directions, and key aspects that could have an impact on the future of this field.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalJournal of Nuclear Medicine
Volume61
Issue number1
DOIs
StatePublished - Jan 2020

Keywords

  • Bimodal tracers
  • Fluorescence imaging
  • Image-guided surgery
  • Multimodal
  • Nuclear medicine

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    van Leeuwen, F. W. B., Schottelius, M., Brouwer, O. R., Vidal-Sicart, S., Achilefu, S., Klode, J., Wester, H. J., & Buckle, T. (2020). Trending: Radioactive and fluorescent bimodal/hybrid tracers as multiplexing solutions for surgical guidance. Journal of Nuclear Medicine, 61(1), 13-19. https://doi.org/10.2967/jnumed.119.228684