TREM2 R47H variant as a risk factor for early-onset alzheimer's disease

Cyril Pottier; David Wallon; Stephane Rousseau; Anne Rovelet-Lecrux; Anne Claire Richard; Adeline Rollin-Sillaire; Thierry Frebourg; Dominique Campion; Didier Hannequin

doi:10.3233/JAD-122311

TREM2 R47H variant as a risk factor for early-onset alzheimer's disease

Cyril Pottier
, David Wallon
, Stephane Rousseau
, Anne Rovelet-Lecrux
, Anne Claire Richard
, Adeline Rollin-Sillaire
, Thierry Frebourg
, Dominique Campion
, Didier Hannequin

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

The rs75932628-T variant of the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has recently been identified as a rare risk factor for late-onset Alzheimer's disease (AD). In this study we examined the association between TREM2 exon 2 variants and early-onset AD in a sample of Caucasian subjects of French origin including 726 patients with age of onset ≤65 years and 783 controls. Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95% CI, 1.3 to 16.9; p = 0.009). These results confirm the association between this variant and AD and underline its involvement in early-onset cases.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	35
Issue number	1
DOIs	https://doi.org/10.3233/JAD-122311
State	Published - 2013

Keywords

Early onset Alzheimer's disease
rare variant
risk factor
TREM2

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10.3233/JAD-122311

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title = "TREM2 R47H variant as a risk factor for early-onset alzheimer's disease",

abstract = "The rs75932628-T variant of the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has recently been identified as a rare risk factor for late-onset Alzheimer's disease (AD). In this study we examined the association between TREM2 exon 2 variants and early-onset AD in a sample of Caucasian subjects of French origin including 726 patients with age of onset ≤65 years and 783 controls. Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95\% CI, 1.3 to 16.9; p = 0.009). These results confirm the association between this variant and AD and underline its involvement in early-onset cases.",

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year = "2013",

doi = "10.3233/JAD-122311",

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AU - Pottier, Cyril

AU - Wallon, David

AU - Rousseau, Stephane

AU - Rovelet-Lecrux, Anne

AU - Richard, Anne Claire

AU - Rollin-Sillaire, Adeline

AU - Frebourg, Thierry

AU - Campion, Dominique

AU - Hannequin, Didier

PY - 2013

Y1 - 2013

N2 - The rs75932628-T variant of the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has recently been identified as a rare risk factor for late-onset Alzheimer's disease (AD). In this study we examined the association between TREM2 exon 2 variants and early-onset AD in a sample of Caucasian subjects of French origin including 726 patients with age of onset ≤65 years and 783 controls. Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95% CI, 1.3 to 16.9; p = 0.009). These results confirm the association between this variant and AD and underline its involvement in early-onset cases.

AB - The rs75932628-T variant of the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has recently been identified as a rare risk factor for late-onset Alzheimer's disease (AD). In this study we examined the association between TREM2 exon 2 variants and early-onset AD in a sample of Caucasian subjects of French origin including 726 patients with age of onset ≤65 years and 783 controls. Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95% CI, 1.3 to 16.9; p = 0.009). These results confirm the association between this variant and AD and underline its involvement in early-onset cases.

KW - Early onset Alzheimer's disease

KW - rare variant

KW - risk factor

KW - TREM2

UR - https://www.scopus.com/pages/publications/84876398977

U2 - 10.3233/JAD-122311

DO - 10.3233/JAD-122311

M3 - Article

AN - SCOPUS:84876398977

SN - 1387-2877

VL - 35

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EP - 49

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 1

ER -

TREM2 R47H variant as a risk factor for early-onset alzheimer's disease

Abstract

Keywords

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