TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Martina Molgora, Ekaterina Esaulova, William Vermi, Jinchao Hou, Yun Chen, Jingqin Luo, Simone Brioschi, Mattia Bugatti, Andrea Salvatore Omodei, Biancamaria Ricci, Catrina Fronick, Santosh K. Panda, Yoshiko Takeuchi, Matthew M. Gubin, Roberta Faccio, Marina Cella, Susan Gilfillan, Emil R. Unanue, Maksym Artomov, Robert D. SchreiberMarco Colonna

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.

Original languageEnglish
Pages (from-to)886-900.e17
JournalCell
Volume182
Issue number4
DOIs
StatePublished - Aug 20 2020

Keywords

  • breast cancer
  • checkpoint blockade
  • colorectal cancer
  • human
  • macrophages
  • sarcoma
  • TREM2
  • tumor

Fingerprint Dive into the research topics of 'TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy'. Together they form a unique fingerprint.

Cite this