107 Scopus citations

Abstract

TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.

Original languageEnglish
Pages (from-to)886-900.e17
JournalCell
Volume182
Issue number4
DOIs
StatePublished - Aug 20 2020

Keywords

  • TREM2
  • breast cancer
  • checkpoint blockade
  • colorectal cancer
  • human
  • macrophages
  • sarcoma
  • tumor

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