TREM2 function impedes tau seeding in neuritic plaques

Cheryl E.G. Leyns, Maud Gratuze, Sneha Narasimhan, Nimansha Jain, Lauren J. Koscal, Hong Jiang, Melissa Manis, Marco Colonna, Virginia M.Y. Lee, Jason D. Ulrich, David M. Holtzman

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer’s disease. Here we show that germline knockout of Trem2 or the TREM2R47H variant reduces microgliosis around amyloid-β plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates. These findings demonstrate a key role for TREM2 and microglia in limiting the development of peri-plaque tau pathologies.

Original languageEnglish
Pages (from-to)1217-1222
Number of pages6
JournalNature neuroscience
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2019

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