Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer’s disease. Here we show that germline knockout of Trem2 or the TREM2R47H variant reduces microgliosis around amyloid-β plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates. These findings demonstrate a key role for TREM2 and microglia in limiting the development of peri-plaque tau pathologies.

Original languageEnglish
Pages (from-to)1217-1222
Number of pages6
JournalNature neuroscience
Issue number8
StatePublished - Aug 1 2019


Dive into the research topics of 'TREM2 function impedes tau seeding in neuritic plaques'. Together they form a unique fingerprint.

Cite this