TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Jinchao Hou; Yun Chen; Gary Grajales-Reyes; Marco Colonna

doi:10.1186/s13024-022-00588-y

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonna

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD.

Original language	English
Article number	84
Journal	Molecular neurodegeneration
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s13024-022-00588-y
State	Published - Dec 2022

Keywords

APOE
Alzheimer’s disease
Beta-amyloid pathology
Demyelination
Microglia
TREM2
Tauopathy

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10.1186/s13024-022-00588-y

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abstract = "Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer{\textquoteright}s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD.",

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AU - Hou, Jinchao

AU - Chen, Yun

AU - Grajales-Reyes, Gary

AU - Colonna, Marco

PY - 2022/12

Y1 - 2022/12

N2 - Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD.

AB - Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD.

KW - APOE

KW - Alzheimer’s disease

KW - Beta-amyloid pathology

KW - Demyelination

KW - Microglia

KW - TREM2

KW - Tauopathy

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JO - Molecular neurodegeneration

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TREM2 dependent and independent functions of microglia in Alzheimer’s disease

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