TY - JOUR
T1 - TREM2 and microglia exosomes
T2 - a potential highway for pathological tau
AU - Jain, Nimansha
AU - Ulrich, Jason D.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Tau pathology appears to spread along neuronal networks via the template misfolding of tau by pathological tau conformations. The mechanisms underlying neuron-to-neuron transmission of tau are unclear and recent work demonstrates a role for microglia in the spread of tau pathology. In this Commentary, we discuss a recent study that found that loss of TREM2 expression resulted in exacerbated spread of tau pathology that depended on microglial exosomes. These important findings highlight the role of the microglial endolysosomal system and TREM2 in the spread of tau pathology.
AB - Tau pathology appears to spread along neuronal networks via the template misfolding of tau by pathological tau conformations. The mechanisms underlying neuron-to-neuron transmission of tau are unclear and recent work demonstrates a role for microglia in the spread of tau pathology. In this Commentary, we discuss a recent study that found that loss of TREM2 expression resulted in exacerbated spread of tau pathology that depended on microglial exosomes. These important findings highlight the role of the microglial endolysosomal system and TREM2 in the spread of tau pathology.
UR - http://www.scopus.com/inward/record.url?scp=85142149772&partnerID=8YFLogxK
U2 - 10.1186/s13024-022-00581-5
DO - 10.1186/s13024-022-00581-5
M3 - Comment/debate
C2 - 36397070
AN - SCOPUS:85142149772
SN - 1750-1326
VL - 17
JO - Molecular neurodegeneration
JF - Molecular neurodegeneration
IS - 1
M1 - 73
ER -