TREM2 and microglia exosomes: a potential highway for pathological tau

Nimansha Jain, Jason D. Ulrich

Research output: Contribution to journalComment/debate

8 Scopus citations

Abstract

Tau pathology appears to spread along neuronal networks via the template misfolding of tau by pathological tau conformations. The mechanisms underlying neuron-to-neuron transmission of tau are unclear and recent work demonstrates a role for microglia in the spread of tau pathology. In this Commentary, we discuss a recent study that found that loss of TREM2 expression resulted in exacerbated spread of tau pathology that depended on microglial exosomes. These important findings highlight the role of the microglial endolysosomal system and TREM2 in the spread of tau pathology.

Original languageEnglish
Article number73
JournalMolecular neurodegeneration
Volume17
Issue number1
DOIs
StatePublished - Dec 2022

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