TREM2: A new player in the tumor microenvironment

Martina Molgora; Yizhou A. Liu; Marco Colonna; Marina Cella

doi:10.1016/j.smim.2023.101739

TREM2: A new player in the tumor microenvironment

Martina Molgora, Yizhou A. Liu, Marco Colonna, Marina Cella

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.

Original language	English
Article number	101739
Journal	Seminars in immunology
Volume	67
DOIs	https://doi.org/10.1016/j.smim.2023.101739
State	Published - May 2023

Keywords

Cancer
Immunotherapy
Macrophages
TREM2

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10.1016/j.smim.2023.101739

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title = "TREM2: A new player in the tumor microenvironment",

abstract = "TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.",

keywords = "Cancer, Immunotherapy, Macrophages, TREM2",

author = "Martina Molgora and Liu, {Yizhou A.} and Marco Colonna and Marina Cella",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

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doi = "10.1016/j.smim.2023.101739",

language = "English",

volume = "67",

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T2 - A new player in the tumor microenvironment

AU - Molgora, Martina

AU - Liu, Yizhou A.

AU - Colonna, Marco

AU - Cella, Marina

PY - 2023/5

Y1 - 2023/5

N2 - TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.

AB - TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.

KW - Cancer

KW - Immunotherapy

KW - Macrophages

KW - TREM2

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U2 - 10.1016/j.smim.2023.101739

DO - 10.1016/j.smim.2023.101739

M3 - Review article

C2 - 36989543

AN - SCOPUS:85150840341

SN - 1044-5323

VL - 67

JO - Seminars in immunology

JF - Seminars in immunology

M1 - 101739

ER -

TREM2: A new player in the tumor microenvironment

Abstract

Keywords

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