@article{2902f64455244445b3bd4966aa465690,
title = "TREM2: A new player in the tumor microenvironment",
abstract = "TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.",
keywords = "Cancer, Immunotherapy, Macrophages, TREM2",
author = "Martina Molgora and Liu, {Yizhou A.} and Marco Colonna and Marina Cella",
note = "Funding Information: Martina Molgora is a recipient of the Cancer Research Institute-Lloyd J. Old Memorial Fellowship in Tumor Immunology. Marco Colonna is supported by the National Institutes of Health (R01 CA262684). Figures were created with BioRender.com. Funding Information: Martina Molgora is a recipient of the Cancer Research Institute-Lloyd J. Old Memorial Fellowship in Tumor Immunology . Marco Colonna is supported by the National Institutes of Health ( R01 CA262684 ). Figures were created with BioRender.com. Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",
year = "2023",
month = may,
doi = "10.1016/j.smim.2023.101739",
language = "English",
volume = "67",
journal = "Seminars in immunology",
issn = "1044-5323",
}