TREM1 Blockade: Killing Two Birds with One Stone

Marco Colonna

doi:10.1016/j.it.2019.07.008

TREM1 Blockade: Killing Two Birds with One Stone

Marco Colonna

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Infectious and sterile injuries cause the release of PAMPs and DAMPs. A study by Liu et al. (Nat. Immunol. 2019) reports that DAMP-induced sterile brain inflammation from stroke is associated with sympathetic nervous system activation, enhancing intestinal permeability, the release of microbiota-derived PAMPs, and inflammation. TREM1 is implicated as a potential target to treat stroke and DAMP- and PAMP-induced inflammation.

Original language	English
Pages (from-to)	781-783
Number of pages	3
Journal	Trends in Immunology
Volume	40
Issue number	9
DOIs	https://doi.org/10.1016/j.it.2019.07.008
State	Published - Sep 2019

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title = "TREM1 Blockade: Killing Two Birds with One Stone",

abstract = "Infectious and sterile injuries cause the release of PAMPs and DAMPs. A study by Liu et al. (Nat. Immunol. 2019) reports that DAMP-induced sterile brain inflammation from stroke is associated with sympathetic nervous system activation, enhancing intestinal permeability, the release of microbiota-derived PAMPs, and inflammation. TREM1 is implicated as a potential target to treat stroke and DAMP- and PAMP-induced inflammation.",

author = "Marco Colonna",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

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AB - Infectious and sterile injuries cause the release of PAMPs and DAMPs. A study by Liu et al. (Nat. Immunol. 2019) reports that DAMP-induced sterile brain inflammation from stroke is associated with sympathetic nervous system activation, enhancing intestinal permeability, the release of microbiota-derived PAMPs, and inflammation. TREM1 is implicated as a potential target to treat stroke and DAMP- and PAMP-induced inflammation.

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JO - Trends in Immunology

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TREM1 Blockade: Killing Two Birds with One Stone

Abstract

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