Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

Keyphrases

• Neuroinflammation 100%
• Lysosomal Storage Disease 100%
• Autophagy 100%
• Retinal Degeneration 100%
• Lysosomal Acid Lipase 100%
• Trehalose 100%
• SQSTM1 66%
• Autophagic Vacuoles 66%
• NAGLU 66%
• α-N-acetylglucosaminidase 66%
• Sanfilippo Disease 66%
• Mouse Model 33%
• Hematopoietic Stem Cell Transplantation 33%
• Protein Kinase 33%
• Inflammation 33%
• Glial Fibrillary Acidic Protein 33%
• Small Molecules 33%
• Therapeutic Approaches 33%
• Photosystem II 33%
• Enzyme Replacement Therapy 33%
• ATG7 33%
• Autophagy Pathway 33%
• Autophagic Flux 33%
• PBS Phosphate Buffered Saline 33%
• Microtubule-associated Protein 1 Light Chain 3 33%
• Macroautophagy 33%
• Hyperactivity 33%
• Retina 33%
• Progressive Neurodegeneration 33%
• Glial Cells 33%
• Glyceraldehyde-3-phosphate Dehydrogenase 33%
• G Protein 33%
• Neuronal Cells 33%
• Neurological Symptoms 33%
• Electroretinogram 33%
• Transcriptional Network 33%
• Enzyme Deficiency 33%
• Transcription Factor EB 33%
• Photoreceptor Cells 33%
• Lysosomal Biogenesis 33%
• Functional Deficiency 33%
• Outer nuclear Layer 33%
• Somatosensory Cortex 33%
• CD68 33%
• Inner nuclear Layer 33%
• Small Molecule Therapy 33%
• Abbreviations ANOVA Analysis of Variance 33%
• GNAT2 33%
• Storage Disorders 33%
• GAPDH 33%
• PRKCA 33%
• Mucopolysaccharidosis IIIB 33%
• Lysosomal Enzyme Deficiency 33%
• Molecular Materials 33%
• CD68 Antigen 33%
• PKC Protein Kinase C 33%
• TEM Microscopy 33%

Medicine and Dentistry

• Neuroinflammation 100%
• Hydrolase 100%
• Storage Disease 100%
• Autophagy 100%
• Trehalose 100%
• Retina Degeneration 100%
• Lysosomal Storage Disease 75%
• Analysis of Variance 50%
• Mucopolysaccharidosis 50%
• Sanfilippo Syndrome 50%
• Vacuolization 50%
• Enzyme Deficiency 50%
• Alpha N Acetylglucosaminidase 50%
• Neurodegeneration 25%
• Microglia 25%
• Hematopoietic Stem Cell Transplantation 25%
• Enzyme Replacement Therapy 25%
• Neurologic Disease 25%
• Transcription Factors 25%
• Transmission Electron Microscopy 25%
• Glial Fibrillary Acidic Protein 25%
• Guanine Nucleotide Binding Protein 25%
• Hyperactivity 25%
• Thalamus 25%
• Biogenesis 25%
• Lysosome Enzyme 25%
• Light Chain 25%
• Outer Nuclear Layer 25%
• Somatosensory Cortex 25%
• Chlordane 25%
• Phosphate Buffered Saline 25%
• Macroautophagy 25%
• Microtubule Associated Protein 1 25%
• Inner Nuclear Layer 25%
• Sequestosome 1 25%
• CD68 Antigen 25%
• Protein Kinase C Alpha 25%
• Glyceraldehyde 3 Phosphate Dehydrogenase 25%
• Photoreceptor 25%

Biochemistry, Genetics and Molecular Biology

• Hydrolase 100%
• Trehalose 100%
• Deficiency 100%
• Neuroinflammation 100%
• Enzyme 80%
• Autophagy 80%
• Mucopolysaccharidosis 40%
• Small Molecule 40%
• CD68 40%
• TFEB 40%
• Alpha-N-Acetylglucosaminidase 40%
• Sanfilippo Syndrome 40%
• Mouse Model 20%
• Hematopoietic Stem Cell Transplantation 20%
• Transcription Factors 20%
• Microglia 20%
• Protein Kinase C 20%
• Macroautophagy 20%
• Synapsin I 20%
• Glial Cells 20%
• Biogenesis 20%
• Microtubule-Associated Protein 20%
• Light Chain 20%
• Photoreceptor Cell 20%
• Transmission Electron Microscopy 20%
• Glial Fibrillary Acidic Protein 20%
• Glyceraldehyde 3-Phosphate Dehydrogenase 20%
• Phosphate Buffered Saline 20%
• Sequestosome 1 20%
• G Protein 20%
• Hyperactivity 20%