TY - JOUR
T1 - Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
AU - DeBosch, Brian J.
AU - Heitmeier, Monique R.
AU - Mayer, Allyson L.
AU - Higgins, Cassandra B.
AU - Crowley, Jan R.
AU - Kraft, Thomas E.
AU - Chi, Maggie
AU - Newberry, Elizabeth P.
AU - Chen, Zhouji
AU - Finck, Brian N.
AU - Davidson, Nicholas O.
AU - Yarasheski, Kevin E.
AU - Hruz, Paul W.
AU - Moley, Kelle H.
N1 - Publisher Copyright:
© 2016 by the American Association for the Advancement of Science.
PY - 2016/2/23
Y1 - 2016/2/23
N2 - Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to pathological protein aggregation. Despite decades of ubiquitous use as a nutraceutical, preservative, and humectant, its mechanism of action remains elusive. We showed that trehalose inhibitedmembers of the SLC2A (also known asGLUT) family of glucose transporters. Trehalose-mediated inhibition of glucose transport induced AMPK (adenosine 5'-monophosphate- activated protein kinase)-dependent autophagy and regression of hepatic steatosis in vivo and a reduction in the accumulation of lipid droplets in primarymurine hepatocyte cultures. Our data indicated that trehalose triggers beneficial cellular autophagy by inhibiting glucose transport.
AB - Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to pathological protein aggregation. Despite decades of ubiquitous use as a nutraceutical, preservative, and humectant, its mechanism of action remains elusive. We showed that trehalose inhibitedmembers of the SLC2A (also known asGLUT) family of glucose transporters. Trehalose-mediated inhibition of glucose transport induced AMPK (adenosine 5'-monophosphate- activated protein kinase)-dependent autophagy and regression of hepatic steatosis in vivo and a reduction in the accumulation of lipid droplets in primarymurine hepatocyte cultures. Our data indicated that trehalose triggers beneficial cellular autophagy by inhibiting glucose transport.
UR - http://www.scopus.com/inward/record.url?scp=84959345504&partnerID=8YFLogxK
U2 - 10.1126/scisignal.aac5472
DO - 10.1126/scisignal.aac5472
M3 - Article
C2 - 26905426
AN - SCOPUS:84959345504
SN - 1945-0877
VL - 9
JO - Science signaling
JF - Science signaling
IS - 416
M1 - RA21
ER -