Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib

Lybil Briscia Mendoza Alvarez, Xiuli Liu, Sarah Glover

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic oesophagitis and biopsies were significant for up to 100 eosinophils per high power field during his various treatments. There was a significant improvement in the appearance of the oesophagus as well as the least number of eosinophils found in oesophagus biopsies after 3 months of treatment with tofacitinib. There are no cases of EoE treated with tofacitinib. Tofacitinib should be considered for the treatment of eosinophilic oesophagitis given its evolving role as an immunosuppressive agent.

Original languageEnglish
Article numbere232558
JournalBMJ Case Reports
Volume12
Issue number12
DOIs
StatePublished - Dec 11 2019

Keywords

  • drugs: gastrointestinal system
  • endoscopy
  • gastroenterology
  • oesophagus

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