TY - JOUR
T1 - Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer
AU - Campian, Jian L.
AU - Ye, Xiaobu
AU - Brock, Malcolm
AU - Grossman, Stuart A.
PY - 2013/3
Y1 - 2013/3
N2 - Background: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. Methods: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. Results: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm3, p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6). Conclusions: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.
AB - Background: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. Methods: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. Results: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm3, p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6). Conclusions: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.
KW - Chemotherapy
KW - Lymphopenia
KW - Non-small-cell lung cancer
KW - Radiation
KW - Treatment-related toxicities
UR - http://www.scopus.com/inward/record.url?scp=84875048243&partnerID=8YFLogxK
U2 - 10.3109/07357907.2013.767342
DO - 10.3109/07357907.2013.767342
M3 - Article
C2 - 23432821
AN - SCOPUS:84875048243
SN - 0735-7907
VL - 31
SP - 183
EP - 188
JO - Cancer Investigation
JF - Cancer Investigation
IS - 3
ER -