Treatment options for hypertriglyceridemia: From risk reduction to pancreatitis

Lars Berglund, John D. Brunzell, Anne C. Goldberg, Ira J. Goldberg, Anton Stalenhoef

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


While there has been considerable focus on the role and treatment of LDL cholesterol levels, a definitive role of triglycerides in the management of cardiovascular disease has been uncertain. Notably, with increasing triglyceride levels, there is a parallel increase in cholesterol levels carried by triglyceride-rich lipoproteins, which has prompted interest in the use of non-HDL cholesterol levels as a tool guiding interventions. Recent studies have provided evidence for an independent role of triglyceride levels as a cardiovascular risk factor, and recently, an Endocrine Society guideline was published for treatment of hypertriglyceridemia. In contrast to the relative uncertainty regarding triglycerides and cardiovascular disease, a role of very high triglyceride levels as a risk factor for pancreatitis has been well known. The present paper summarizes the underlying evidence for a risk role for triglyceride levels in cardiovascular disease and pancreatitis, current treatment recommendations and areas of future research.

Original languageEnglish
Pages (from-to)423-437
Number of pages15
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Jun 2014


  • coronary heart disease
  • dyslipidemia
  • hypolipidemic therapy
  • lifestyle intervention
  • lipoproteins


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