Treatment of recurrent Clostridium difficile diarrhea

Elizabeth S. Huebner, Christina M. Surawicz

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Treatment of recurrent Clostridium difficile-associated diarrhea can be challenging. Once patients develop recurrent disease, further episodes are common and can continue for months or even a year or more. Treatment begins with a repeat standard 10-day course of antibiotics, followed by tapering and/or pulsing of the antibiotic dose. Probiotics can also be useful, particularly the nonpathogenic yeast Saccharomyces boulardii. Stool reconstitution via fecal enemas, colonoscopy, and nasogastric tubes have, been performed to restore normal colonic flora. Additional approaches under investigation, such as vaccination against C. difficile, show encouraging preliminary results.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalGastroenterology and Hepatology
Issue number3
StatePublished - Mar 1 2006


  • Lactobacillus GG
  • Metronidazole
  • Recurrent Clostridium difficile-associated disease
  • Saccharomyces boulardii
  • Vancomycin


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