Treatment of ocular disease in eczema herpeticum

T. P. Margolis; H. B. Ostler

doi:10.1016/S0002-9394(14)76344-5

Treatment of ocular disease in eczema herpeticum

T. P. Margolis, H. B. Ostler

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35 Scopus citations

Abstract

Individuals with atopic dermatitis are particularly susceptible to herpes simplex viral infection and may develop dissemination (eczema herpeticum). Additionally, they may develop severe and bilateral herpetic ocular disease. The keratitis is commonly complicated by stromal scarring and slow epithelial healing despite topical antiviral therapy. We treated three patients who had herpetic keratoconjunctivitis associated with eczema herpeticum. In all three cases the keratitis resolved promptly (48 to 72 hours) without residual scarring after treatment with systemic acyclovir and topical trifluridine. The combined use of systemic acyclovir and topical trifluridine may be of similar value in treating all cases of atopic herpetic keratitis.

Original language	English
Pages (from-to)	274-279
Number of pages	6
Journal	American journal of ophthalmology
Volume	110
Issue number	3
DOIs	https://doi.org/10.1016/S0002-9394(14)76344-5
State	Published - 1990

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title = "Treatment of ocular disease in eczema herpeticum",

abstract = "Individuals with atopic dermatitis are particularly susceptible to herpes simplex viral infection and may develop dissemination (eczema herpeticum). Additionally, they may develop severe and bilateral herpetic ocular disease. The keratitis is commonly complicated by stromal scarring and slow epithelial healing despite topical antiviral therapy. We treated three patients who had herpetic keratoconjunctivitis associated with eczema herpeticum. In all three cases the keratitis resolved promptly (48 to 72 hours) without residual scarring after treatment with systemic acyclovir and topical trifluridine. The combined use of systemic acyclovir and topical trifluridine may be of similar value in treating all cases of atopic herpetic keratitis.",

author = "Margolis, {T. P.} and Ostler, {H. B.}",

note = "Funding Information: From the F. 1. Proctor Foundation, University of California at San Francisco Medical Center, San Francisco, California. This study was supported in part by National Eye Institute grant EY3917. Dr. Margolis was a Heed Foundation Fellow (1988-1989). Dr. Margolis was supported in part by National Eye Institute grant EY07058.",

year = "1990",

doi = "10.1016/S0002-9394(14)76344-5",

language = "English",

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T1 - Treatment of ocular disease in eczema herpeticum

AU - Margolis, T. P.

AU - Ostler, H. B.

N1 - Funding Information: From the F. 1. Proctor Foundation, University of California at San Francisco Medical Center, San Francisco, California. This study was supported in part by National Eye Institute grant EY3917. Dr. Margolis was a Heed Foundation Fellow (1988-1989). Dr. Margolis was supported in part by National Eye Institute grant EY07058.

PY - 1990

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N2 - Individuals with atopic dermatitis are particularly susceptible to herpes simplex viral infection and may develop dissemination (eczema herpeticum). Additionally, they may develop severe and bilateral herpetic ocular disease. The keratitis is commonly complicated by stromal scarring and slow epithelial healing despite topical antiviral therapy. We treated three patients who had herpetic keratoconjunctivitis associated with eczema herpeticum. In all three cases the keratitis resolved promptly (48 to 72 hours) without residual scarring after treatment with systemic acyclovir and topical trifluridine. The combined use of systemic acyclovir and topical trifluridine may be of similar value in treating all cases of atopic herpetic keratitis.

AB - Individuals with atopic dermatitis are particularly susceptible to herpes simplex viral infection and may develop dissemination (eczema herpeticum). Additionally, they may develop severe and bilateral herpetic ocular disease. The keratitis is commonly complicated by stromal scarring and slow epithelial healing despite topical antiviral therapy. We treated three patients who had herpetic keratoconjunctivitis associated with eczema herpeticum. In all three cases the keratitis resolved promptly (48 to 72 hours) without residual scarring after treatment with systemic acyclovir and topical trifluridine. The combined use of systemic acyclovir and topical trifluridine may be of similar value in treating all cases of atopic herpetic keratitis.

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Treatment of ocular disease in eczema herpeticum

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