Treatment of metastatic rhabdoid tumor of the kidney

Lars Wagner, D. Ashley Hill, Christine Fuller, Márcia Pedrosa, Manoo Bhakta, Arie Perry, Jeffrey S. Dome

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Metastatic rhabdoid tumor of the kidney (RTK) is a highly lethal malignancy; only one survivor with stage 4 disease has been reported. The authors reviewed the cases of two patients with metastatic RTK who had excellent responses to therapy. Both patients were treated with radiation therapy and alternating courses of ifosfamide, carboplatin, and etoposide (ICE) and vincristine, doxorubicin, and cyclophosphamide (VDC). The patients are without evidence of disease at 24 months and 12 months from the detection of metastasis. Alternating courses of ICE and VDC have activity against metastatic RTK. This combination of agents warrants prospective investigation in clinical trials.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Issue number5
StatePublished - 2002


  • Atypical teratoid/rhabdoid tumor
  • INI-1
  • Rhabdoid tumor
  • Snf5
  • Wilms tumor


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