Treatment of metastatic rhabdoid tumor of the kidney

Lars Wagner; D. Ashley Hill; Christine Fuller; Márcia Pedrosa; Manoo Bhakta; Arie Perry; Jeffrey S. Dome

doi:10.1097/00043426-200206000-00012

Treatment of metastatic rhabdoid tumor of the kidney

Lars Wagner, D. Ashley Hill, Christine Fuller, Márcia Pedrosa, Manoo Bhakta, Arie Perry, Jeffrey S. Dome

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56 Scopus citations

Abstract

Metastatic rhabdoid tumor of the kidney (RTK) is a highly lethal malignancy; only one survivor with stage 4 disease has been reported. The authors reviewed the cases of two patients with metastatic RTK who had excellent responses to therapy. Both patients were treated with radiation therapy and alternating courses of ifosfamide, carboplatin, and etoposide (ICE) and vincristine, doxorubicin, and cyclophosphamide (VDC). The patients are without evidence of disease at 24 months and 12 months from the detection of metastasis. Alternating courses of ICE and VDC have activity against metastatic RTK. This combination of agents warrants prospective investigation in clinical trials.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	Journal of Pediatric Hematology/Oncology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1097/00043426-200206000-00012
State	Published - 2002

Keywords

Atypical teratoid/rhabdoid tumor
INI-1
Rhabdoid tumor
Snf5
Wilms tumor

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abstract = "Metastatic rhabdoid tumor of the kidney (RTK) is a highly lethal malignancy; only one survivor with stage 4 disease has been reported. The authors reviewed the cases of two patients with metastatic RTK who had excellent responses to therapy. Both patients were treated with radiation therapy and alternating courses of ifosfamide, carboplatin, and etoposide (ICE) and vincristine, doxorubicin, and cyclophosphamide (VDC). The patients are without evidence of disease at 24 months and 12 months from the detection of metastasis. Alternating courses of ICE and VDC have activity against metastatic RTK. This combination of agents warrants prospective investigation in clinical trials.",

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AU - Wagner, Lars

AU - Ashley Hill, D.

AU - Fuller, Christine

AU - Pedrosa, Márcia

AU - Bhakta, Manoo

AU - Perry, Arie

AU - Dome, Jeffrey S.

PY - 2002

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AB - Metastatic rhabdoid tumor of the kidney (RTK) is a highly lethal malignancy; only one survivor with stage 4 disease has been reported. The authors reviewed the cases of two patients with metastatic RTK who had excellent responses to therapy. Both patients were treated with radiation therapy and alternating courses of ifosfamide, carboplatin, and etoposide (ICE) and vincristine, doxorubicin, and cyclophosphamide (VDC). The patients are without evidence of disease at 24 months and 12 months from the detection of metastasis. Alternating courses of ICE and VDC have activity against metastatic RTK. This combination of agents warrants prospective investigation in clinical trials.

KW - Atypical teratoid/rhabdoid tumor

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KW - Rhabdoid tumor

KW - Snf5

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Treatment of metastatic rhabdoid tumor of the kidney

Abstract

Keywords

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