TY - JOUR
T1 - Treatment of conjunctival squamous cell carcinoma with topical cidofovir
AU - Sherman, Mark D.
AU - Feldman, Kenneth A.
AU - Farahmand, Shirin M.
AU - Margolis, Todd P.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002/9
Y1 - 2002/9
N2 - PURPOSE: To describe a case of conjunctival squamous cell carcinoma in situ that was successfully treated with adjunctive topical cidofovir. DESIGN: Interventional case report. METHODS: A 52-year-old woman presented with a diagnosis of diffuse conjunctival papillomatosis in the right eye. She underwent conjunctival biopsy followed by a 6-week course of cidofovir eyedrops (2.5 mg/ml). RESULTS: The biopsy specimen demonstrated squamous cell carcinoma in situ. After this biopsy and treatment with cidofovir, the mass regressed into a small vascular tuft, which was excised and treated with cryotherapy. Six months after cidofovir treatment, the patient developed cicatricial changes of the inferior punctum. No recurrence of the squamous cell carcinoma has occurred in 24 months of follow-up. CONCLUSION: Cidofovir has shown effectiveness in the treatment of neoplastic lesions involving various mucus membrane sites. This antiviral drug may be a valuable addition to our treatment armamentarium for patients with squamous cell carcinoma in situ of the conjunctiva. The possible relationship between topical cidofovir and cicatricial changes of the lacrimal system cannot be determined from this isolated report, but further investigation is indicated.
AB - PURPOSE: To describe a case of conjunctival squamous cell carcinoma in situ that was successfully treated with adjunctive topical cidofovir. DESIGN: Interventional case report. METHODS: A 52-year-old woman presented with a diagnosis of diffuse conjunctival papillomatosis in the right eye. She underwent conjunctival biopsy followed by a 6-week course of cidofovir eyedrops (2.5 mg/ml). RESULTS: The biopsy specimen demonstrated squamous cell carcinoma in situ. After this biopsy and treatment with cidofovir, the mass regressed into a small vascular tuft, which was excised and treated with cryotherapy. Six months after cidofovir treatment, the patient developed cicatricial changes of the inferior punctum. No recurrence of the squamous cell carcinoma has occurred in 24 months of follow-up. CONCLUSION: Cidofovir has shown effectiveness in the treatment of neoplastic lesions involving various mucus membrane sites. This antiviral drug may be a valuable addition to our treatment armamentarium for patients with squamous cell carcinoma in situ of the conjunctiva. The possible relationship between topical cidofovir and cicatricial changes of the lacrimal system cannot be determined from this isolated report, but further investigation is indicated.
UR - http://www.scopus.com/inward/record.url?scp=0036742065&partnerID=8YFLogxK
U2 - 10.1016/S0002-9394(02)01569-6
DO - 10.1016/S0002-9394(02)01569-6
M3 - Article
C2 - 12208255
AN - SCOPUS:0036742065
SN - 0002-9394
VL - 134
SP - 432
EP - 433
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 3
ER -