TY - JOUR
T1 - Treatment decision-making in acute myeloid leukemia
T2 - a qualitative study of older adults and community oncologists
AU - Loh, Kah Poh
AU - Abdallah, Maya
AU - Kadambi, Sindhuja
AU - Wells, Megan
AU - Kumar, Anita J.
AU - Mendler, Jason H.
AU - Liesveld, Jane L.
AU - Wittink, Marsha
AU - O’Dwyer, Kristen
AU - Becker, Michael W.
AU - McHugh, Colin
AU - Stock, Wendy
AU - Majhail, Navneet S.
AU - Wildes, Tanya M.
AU - Duberstein, Paul
AU - Mohile, Supriya Gupta
AU - Klepin, Heidi D.
N1 - Funding Information:
The work was supported by the National Cancer Institute at the National Institute of Health [UG1 CA189961]; [K99CA237744 to KPL], the National Institute of Aging at the National Institute of Health [K24 AG056589 to SGM], and the Wilmot Research Fellowship Award (to KPL). We wish to acknowledge Dr. Susan Rosenthal, MD for her editorial assistance and Ms. Shuhan Yang for her assistance with creation of figures.
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Little is known about the characteristics of patients, physicians, and organizations that influence treatment decisions in older patients with AML. We conducted qualitative interviews with community oncologists and older patients with AML to elicit factors that influence their treatment decision-making. Recruitment was done via purposive sampling and continued until theoretical saturation was reached, resulting in the inclusion of 15 patients and 15 oncologists. Participants’ responses were analyzed using directed content analysis. Oncologists and patients considered comorbidities, functional status, emotional health, cognition, and social factors when deciding treatment; most oncologists evaluated these using clinical gestalt. Sixty-seven percent of patients perceived that treatment was their only option and that they had not been offered a choice. In conclusion, treatment decision-making is complex and influenced by patient-related factors. These factors can be assessed as part of a geriatric assessment which can help oncologists better determine fitness and guide treatment decision-making.
AB - Little is known about the characteristics of patients, physicians, and organizations that influence treatment decisions in older patients with AML. We conducted qualitative interviews with community oncologists and older patients with AML to elicit factors that influence their treatment decision-making. Recruitment was done via purposive sampling and continued until theoretical saturation was reached, resulting in the inclusion of 15 patients and 15 oncologists. Participants’ responses were analyzed using directed content analysis. Oncologists and patients considered comorbidities, functional status, emotional health, cognition, and social factors when deciding treatment; most oncologists evaluated these using clinical gestalt. Sixty-seven percent of patients perceived that treatment was their only option and that they had not been offered a choice. In conclusion, treatment decision-making is complex and influenced by patient-related factors. These factors can be assessed as part of a geriatric assessment which can help oncologists better determine fitness and guide treatment decision-making.
KW - Treatment decision-making
KW - acute myeloid leukemia
KW - geriatric hematology
KW - older adults
UR - http://www.scopus.com/inward/record.url?scp=85092394083&partnerID=8YFLogxK
U2 - 10.1080/10428194.2020.1832662
DO - 10.1080/10428194.2020.1832662
M3 - Article
C2 - 33040623
AN - SCOPUS:85092394083
SN - 1042-8194
VL - 62
SP - 387
EP - 398
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 2
ER -