TY - JOUR
T1 - Treatment and outcomes of patients with primary breast sarcoma
AU - Fields, Ryan C.
AU - Aft, Rebecca L.
AU - Gillanders, William E.
AU - Eberlein, Timothy J.
AU - Margenthaler, Julie A.
PY - 2008/10
Y1 - 2008/10
N2 - Background: Surgery is the main treatment for primary breast sarcoma (PBS). Here we characterize this disease and determine factors associated with use of adjuvant therapy. Methods: Records of patients with PBS from 1986 to 2006 were reviewed. Overall survival (OS) was estimated by Kaplan-Meier. Relationships between patient variables and OS were determined using univariate Cox proportional hazard models. Results: Thirteen patients with PBS were identified; 10 patients underwent mastectomy, and 3 underwent partial mastectomy. Six patients underwent axillary staging; none were positive. Patients with tumors >5 cm were more likely to undergo radiation therapy (P <.05). Local recurrence occurred in 7 patients. Metastatic disease was present in 2 patients at diagnosis, and 6 patients developed metastatic disease; all 8 patients died from their disease. Five patients remained disease free. Five-year OS was 67% (83% for tumors <5 cm and 42% for tumors >5 cm). Tumor size was significantly associated with OS (relative risk = 1.1/1 cm increase in size > 5 cm). Conclusions: Treatment for PBS is excision to clear margins. Axillary staging is not indicated. Tumor size >5 cm is the only significant prognostic indicator of overall survival.
AB - Background: Surgery is the main treatment for primary breast sarcoma (PBS). Here we characterize this disease and determine factors associated with use of adjuvant therapy. Methods: Records of patients with PBS from 1986 to 2006 were reviewed. Overall survival (OS) was estimated by Kaplan-Meier. Relationships between patient variables and OS were determined using univariate Cox proportional hazard models. Results: Thirteen patients with PBS were identified; 10 patients underwent mastectomy, and 3 underwent partial mastectomy. Six patients underwent axillary staging; none were positive. Patients with tumors >5 cm were more likely to undergo radiation therapy (P <.05). Local recurrence occurred in 7 patients. Metastatic disease was present in 2 patients at diagnosis, and 6 patients developed metastatic disease; all 8 patients died from their disease. Five patients remained disease free. Five-year OS was 67% (83% for tumors <5 cm and 42% for tumors >5 cm). Tumor size was significantly associated with OS (relative risk = 1.1/1 cm increase in size > 5 cm). Conclusions: Treatment for PBS is excision to clear margins. Axillary staging is not indicated. Tumor size >5 cm is the only significant prognostic indicator of overall survival.
KW - Breast cancer
KW - Sarcoma
KW - Survival
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=52049089471&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2008.06.010
DO - 10.1016/j.amjsurg.2008.06.010
M3 - Article
C2 - 18723152
AN - SCOPUS:52049089471
SN - 0002-9610
VL - 196
SP - 559
EP - 561
JO - American journal of surgery
JF - American journal of surgery
IS - 4
ER -