Treating prepartum depression to improve infant developmental outcomes: A study of diabetes in pregnancy

Tassy Hayden, Dana C. Perantie, Billy D. Nix, Linda D. Barnes, Dorothea J. Mostello, William L. Holcomb, Dragan M. Svrakic, Jeffrey F. Scherrer, Patrick J. Lustman, Tamara Hershey

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Whether and how the co-occurrence of depression and diabetes in pregnancy may worsen infant development has not been reported. Pregnant women with diabetes and with (n = 34) or without (n = 34) major depressive disorder (MDD) were followed during pregnancy and 6-months postpartum. The MDD subset received randomly assigned treatment with cognitive behavior therapy (CBT) or supportive counseling (SC). Depression severity was measured with the Beck Depression Inventory (BDI); infant developmental outcomes were measured with the Bayley Scales of Infant Development (BSID) and its Behavior Rating Scale (BRS). Infants of women with MDD had lower BRS scores (p = .02). Reduction in depression scores was associated with better infant outcomes on the BSID and BRS (p values <.03). These preliminary findings suggest depression occurring in pregnant women with diabetes is associated with poorer infant development and improvement in prepartum depression is associated with improvement in measures of infant development.

Original languageEnglish
Pages (from-to)285-292
Number of pages8
JournalJournal of clinical psychology in medical settings
Issue number3
StatePublished - Sep 2012


  • Depression
  • Diabetes
  • Infant development
  • Pregnancy


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