Treating fatty liver disease by modulating mitochondrial pyruvate metabolism

Jerry R. Colca; William G. McDonald; Kyle McCommis; Brian N. Finck

doi:10.1002/hep4.1036

Treating fatty liver disease by modulating mitochondrial pyruvate metabolism

Jerry R. Colca, William G. McDonald, Kyle McCommis, Brian N. Finck

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Modifying the entry of pyruvate into mitochondria may provide a unique approach to treat metabolic disease. The pharmacology of a new class of insulin sensitizers directed against a newly identified mitochondrial target may treat many aspects of nonalcoholic steatohepatitis, including fibrosis. This commentary suggests treating nonalcoholic steatohepatitis through a newly identified mechanism consistent with pathophysiology. (Hepatology Communications 2017;1:193-197).

Original language	English
Pages (from-to)	193-197
Number of pages	5
Journal	Hepatology Communications
Volume	1
Issue number	3
DOIs	https://doi.org/10.1002/hep4.1036
State	Published - 2017

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10.1002/hep4.1036

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title = "Treating fatty liver disease by modulating mitochondrial pyruvate metabolism",

abstract = "Modifying the entry of pyruvate into mitochondria may provide a unique approach to treat metabolic disease. The pharmacology of a new class of insulin sensitizers directed against a newly identified mitochondrial target may treat many aspects of nonalcoholic steatohepatitis, including fibrosis. This commentary suggests treating nonalcoholic steatohepatitis through a newly identified mechanism consistent with pathophysiology. (Hepatology Communications 2017;1:193-197).",

author = "Colca, {Jerry R.} and McDonald, {William G.} and Kyle McCommis and Finck, {Brian N.}",

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Treating fatty liver disease by modulating mitochondrial pyruvate metabolism

Abstract

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