Treating fatty liver disease by modulating mitochondrial pyruvate metabolism

Jerry R. Colca, William G. McDonald, Kyle McCommis, Brian N. Finck

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Modifying the entry of pyruvate into mitochondria may provide a unique approach to treat metabolic disease. The pharmacology of a new class of insulin sensitizers directed against a newly identified mitochondrial target may treat many aspects of nonalcoholic steatohepatitis, including fibrosis. This commentary suggests treating nonalcoholic steatohepatitis through a newly identified mechanism consistent with pathophysiology. (Hepatology Communications 2017;1:193-197).

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalHepatology Communications
Issue number3
StatePublished - 2017


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