@article{c291a78a2a3b47bbb5c453ea78e5d763,
title = "Traumatic brain injury history is associated with earlier age of onset of frontotemporal dementia",
abstract = "Objective: We retrospectively examined whether a history of traumatic brain injury (TBI) is associated with an earlier age of symptom onset and diagnosis in a large sample of patients with behavioural variant frontotemporal dementia (bvFTD). Methods: Data on patients with bvFTD (n=678) were obtained from the National Alzheimer's Coordinating Center Uniform Data Set. TBI was categorised based on reported lifetime history of TBI with loss of consciousness (LOC) but no chronic deficits occurring more than 1 year prior to diagnosis of bvFTD. Analysis of covariance (ANCOVA) was used to determine if clinician-estimated age of symptom onset and age at diagnosis of bvFTD differed between those who reported a history of TBI with LOC (TBI+) and those who did not (TBI-). Results: Controlling for sex, the TBI+ bvFTD group had an age of symptom onset and age of diagnosis that was on average 2.8 and 3.2 years earlier (p<0.01) than the TBI-bvFTD group. Conclusions: TBI history with LOC occurring more than 1 year prior to diagnosis is associated with an earlier age of symptom onset and diagnosis in patients with bvFTD. TBI may be related to the underlying neurodegenerative processes in bvFTD, but the implications of age at time of injury, severity and repetitive injuries remain unclear.",
author = "Christian LoBue and Kristin Wilmoth and Cullum, {C. Munro} and Rossetti, {Heidi C.} and Lacritz, {Laura H.} and Hynan, {Linda S.} and John Hart and Womack, {Kyle B.}",
note = "Funding Information: This study was provided funding in part by the NIH/NIA P30 AG012300 Alzheimer's Disease Center grant. The NACC database is funded by NIA/NIH grant U01 AG016976. NACC data are contributed by the NIA funded: P30 AG019610 (PI Eric Reiman, MD), P30 AG013846 (PI Neil Kowall, MD), P50 AG008702 (PI Scott Small, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn Albert, PhD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG016574 (PI Ronald Petersen, MD, PhD), P50 AG005138 (PI Mary Sano, PhD), P30 AG008051 (PI Steven Ferris, PhD), P30 AG013854 (PI M Marsel Mesulam, MD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P30 AG010129 (PI Charles DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG016570 (PI David Teplow, PhD), P50 AG005131 (PI Douglas Galasko, MD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982 (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD), P30 AG010124 (PI John Trojanowski, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005142 (PI Helena Chui, MD), P30 AG012300 (PI Roger Rosenberg, MD), P50 AG005136 (PI Thomas Montine, MD, PhD), P50 AG033514 (PI Sanjay Asthana, MD, FRCP), and P50 AG005681 (PI John Morris, MD), P50 AG000000 (PI Bruce Wayne and Co-PI Richard Grayson, Gotham City Concussion Study). The Alzheimer's Disease Genetic Consortium (ADGC) is funded by NIA grant U01 AG032984. Publisher Copyright: {\textcopyright} 2016 Published by the BMJ Publishing Group Limited.",
year = "2016",
month = jan,
day = "8",
doi = "10.1136/jnnp-2015-311438",
language = "English",
volume = "87",
pages = "817--820",
journal = "Journal of Neurology Neurosurgery and Psychiatry",
issn = "0022-3050",
number = "8",
}