Transvaginal fast-scanning optical-resolution photoacoustic endoscopy

Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn MeyenburgJennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald McCarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zou, Molly J. Stout, Methodius Tuuli, Lihong V. Wang

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Photoacoustic endoscopy offers in vivo examination of the visceral tissue using endogenous contrast, but its typical B-scan rate is ∼10 Hz, restricted by the speed of the scanning unit and the laser pulse repetition rate. Here, we present a transvaginal fast-scanning optical-resolution photoacoustic endoscope with a 250-Hz B-scan rate over a 3-mm scanning range. Using this modality, we not only illustrated the morphological differences of vasculatures among the human ectocervix, uterine body, and sublingual mucosa but also showed the longitudinal and cross-sectional differences of cervical vasculatures in pregnant women. This technology is promising for screening the visceral pathological changes associated with angiogenesis.

Original languageEnglish
Article number121617
JournalJournal of biomedical optics
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2018

Keywords

  • cervical imaging
  • fast scanning
  • microelectromechanical system scanning mirror
  • optical-resolution photoacoustic endoscopy

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    Qu, Y., Li, C., Shi, J., Chen, R., Xu, S., Rafsanjani, H., Maslov, K., Krigman, H., Garvey, L., Hu, P., Zhao, P., Meyers, K., Diveley, E., Pizzella, S., Muench, L., Punyamurthy, N., Goldstein, N., Onwumere, O., Alisio, M., ... Wang, L. V. (2018). Transvaginal fast-scanning optical-resolution photoacoustic endoscopy. Journal of biomedical optics, 23(12), [121617]. https://doi.org/10.1117/1.JBO.23.12.121617