TY - JOUR
T1 - Transport of circulating serum cholesterol by human renal cell carcinoma
AU - Clayman, R. V.
AU - Figenshau, R. S.
AU - Prigge, W. F.
AU - Forstrom, L.
AU - Gebhard, R. L.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Clear cell renal cancer contains a large quantity of cholesterol ester (300-mg./gm. protein). To determine whether abnormalities in cholesterol transport could account for this sterol accumulation, the uptake, release, and imaging capabilities of intravenously injected 131I-6-iodomethyl-29-norcholesterol, a cholesterol analogue, were studied preoperatively in five patients with clear cell renal cancer. At surgery, samples of the liver, tumor, adrenal, and non-tumor kidney were obtained for analysis. 131I-sterol uptake by the tumor, when normalized for cholesterol content, was less than for adrenal, liver or kidney. In contrast, release of preloaded 131I-sterol from the human tumors was consistently slower than for normal kidney. The reduced release of free cholesterol from renal cancer cells may, in part, be responsible for the accumulation of cholesterol in human renal cancer.
AB - Clear cell renal cancer contains a large quantity of cholesterol ester (300-mg./gm. protein). To determine whether abnormalities in cholesterol transport could account for this sterol accumulation, the uptake, release, and imaging capabilities of intravenously injected 131I-6-iodomethyl-29-norcholesterol, a cholesterol analogue, were studied preoperatively in five patients with clear cell renal cancer. At surgery, samples of the liver, tumor, adrenal, and non-tumor kidney were obtained for analysis. 131I-sterol uptake by the tumor, when normalized for cholesterol content, was less than for adrenal, liver or kidney. In contrast, release of preloaded 131I-sterol from the human tumors was consistently slower than for normal kidney. The reduced release of free cholesterol from renal cancer cells may, in part, be responsible for the accumulation of cholesterol in human renal cancer.
UR - http://www.scopus.com/inward/record.url?scp=0023204573&partnerID=8YFLogxK
U2 - 10.1016/S0022-5347(17)44478-8
DO - 10.1016/S0022-5347(17)44478-8
M3 - Article
C2 - 3586171
AN - SCOPUS:0023204573
SN - 0022-5347
VL - 137
SP - 1262
EP - 1265
JO - The Journal of Urology
JF - The Journal of Urology
IS - 6
ER -