Transplantation of Human Renal Carcinomas into Athymic Mice

Ralph V. Dayman, Robert S. Figenshau, Amy Bear, Catherine Limas

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28 Scopus citations

Abstract

Thirty-one primary human renal carcinomas were transplanted into athymic mice of which ten produced tumors in the mouse host. Only tumors with a nuclear grade of 3 or 4 were successfully transplanted. The nuclear grades of the human tumor and transplant were similar; however, the cellular histology often varied. Patient prognosis appeared to be inversely related to successful tumor transplantation. In the transplant group, the 1-year survival was 30% in contrast to a 1-year survival of 83% among patients with renal cancers of similar stage and grade which did not produce tumors in the mice.

Original languageEnglish
Pages (from-to)2650-2653
Number of pages4
JournalCancer research
Volume45
Issue number6
StatePublished - Jun 1 1985

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    Dayman, R. V., Figenshau, R. S., Bear, A., & Limas, C. (1985). Transplantation of Human Renal Carcinomas into Athymic Mice. Cancer research, 45(6), 2650-2653.