TY - JOUR
T1 - Transoral Robotic Surgery and De-escalation of Cancer Treatment
AU - Wahle, Benjamin
AU - Zevallos, Jose
N1 - Funding Information:
Research reported in this publication was supported by the National Institute of Deafness and Other Communication Disorders within the National Institutes of Health, through the “Development of Clinician/Researchers in Academic ENT” training grant number T32DC000022. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/12
Y1 - 2020/12
N2 - This article outlines the ways that transoral robotic surgery and transoral laser microsurgery relate to treatment de-escalation in the treatment of head and neck cancer. Treatment de-escalation has particular importance in context of human papillomavirus–related oropharynx squamous cell carcinoma, which responds well to therapy but leaves many survivors with decades of treatment-related sequelae. We compare these less invasive transoral approaches with previously used open approaches to the oropharynx. We discuss the topic of treatment de-escalation in human papillomavirus–related disease and outline completed and ongoing clinical trials investigating the choice of primary treatment modality and de-escalation of adjuvant therapy.
AB - This article outlines the ways that transoral robotic surgery and transoral laser microsurgery relate to treatment de-escalation in the treatment of head and neck cancer. Treatment de-escalation has particular importance in context of human papillomavirus–related oropharynx squamous cell carcinoma, which responds well to therapy but leaves many survivors with decades of treatment-related sequelae. We compare these less invasive transoral approaches with previously used open approaches to the oropharynx. We discuss the topic of treatment de-escalation in human papillomavirus–related disease and outline completed and ongoing clinical trials investigating the choice of primary treatment modality and de-escalation of adjuvant therapy.
KW - Human papillomavirus–associated oropharynx cancer
KW - Squamous cell carcinoma of the oropharynx
KW - Transoral laser microsurgery
KW - Transoral robotic surgery
KW - Treatment de-escalation
KW - Treatment deintensification
UR - http://www.scopus.com/inward/record.url?scp=85090488912&partnerID=8YFLogxK
U2 - 10.1016/j.otc.2020.07.009
DO - 10.1016/j.otc.2020.07.009
M3 - Review article
C2 - 32917423
AN - SCOPUS:85090488912
SN - 0030-6665
VL - 53
SP - 981
EP - 994
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
IS - 6
ER -