Transmitral Flow Velocity-Contour Variation After Premature Ventricular Contractions: A Novel Test of the Load-Independent Index of Diastolic Filling

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The new echocardiography-based, load-independent index of diastolic filling (LIIDF) M was assessed using load-/shape-varying E-waves after premature ventricular contractions (PVCs). Twenty-six PVCs in 15 subjects from a preexisting simultaneous echocardiography-catheterization database were selected. Perturbed load-state beats, defined as the first two post-PVC E-waves, and steady-state E-waves, were subjected to conventional and model-based analysis. M, a dimensionless index, defined by the slope of the peak driving-force vs. peak (filling-opposing) resistive-force regression, was determined from steady-state E-waves alone, and from load-perturbed E-waves combined with a matched number of subsequent beats. Despite high degrees of E-wave shape variation, M derived from load-varying, perturbed beats and M derived from steady-state beats alone were indistinguishable. Because the peak driving-force vs. peak resistive-force relation determining M remains highly linear in the extended E-wave shape and load variation regime observed, we conclude that M is a robust LIIDF. (E-mail: sjk@wuphys.wustl.edu).

Original languageEnglish
Pages (from-to)1901-1908
Number of pages8
JournalUltrasound in Medicine and Biology
Volume34
Issue number12
DOIs
StatePublished - Dec 2008

Keywords

  • Diastole
  • Doppler echocardiography
  • Load-independent index
  • Mathematical modeling

Fingerprint

Dive into the research topics of 'Transmitral Flow Velocity-Contour Variation After Premature Ventricular Contractions: A Novel Test of the Load-Independent Index of Diastolic Filling'. Together they form a unique fingerprint.

Cite this