TY - JOUR
T1 - Transmitral Flow Velocity-Contour Variation After Premature Ventricular Contractions
T2 - A Novel Test of the Load-Independent Index of Diastolic Filling
AU - Boskovski, Marko T.
AU - Shmuylovich, Leonid
AU - Kovács, Sándor J.
N1 - Funding Information:
We gratefully acknowledge the assistance of the Barnes-Jewish Hospital cardiac catheterization laboratory staff. The authors thank Peggy Brown for expert echocardiographic data acquisition. Predoctoral fellowship support for L. S. by the American Heart Association Heartland Affiliate is gratefully acknowledged. This work was also supported by the Whitaker Foundation; National Heart, Lung, and Blood Institute (HL-54179, HL-04023); the Barnes-Jewish Hospital Foundation; and the Alan A. and Edith L. Wolff Charitable Trust.
PY - 2008/12
Y1 - 2008/12
N2 - The new echocardiography-based, load-independent index of diastolic filling (LIIDF) M was assessed using load-/shape-varying E-waves after premature ventricular contractions (PVCs). Twenty-six PVCs in 15 subjects from a preexisting simultaneous echocardiography-catheterization database were selected. Perturbed load-state beats, defined as the first two post-PVC E-waves, and steady-state E-waves, were subjected to conventional and model-based analysis. M, a dimensionless index, defined by the slope of the peak driving-force vs. peak (filling-opposing) resistive-force regression, was determined from steady-state E-waves alone, and from load-perturbed E-waves combined with a matched number of subsequent beats. Despite high degrees of E-wave shape variation, M derived from load-varying, perturbed beats and M derived from steady-state beats alone were indistinguishable. Because the peak driving-force vs. peak resistive-force relation determining M remains highly linear in the extended E-wave shape and load variation regime observed, we conclude that M is a robust LIIDF. (E-mail: [email protected]).
AB - The new echocardiography-based, load-independent index of diastolic filling (LIIDF) M was assessed using load-/shape-varying E-waves after premature ventricular contractions (PVCs). Twenty-six PVCs in 15 subjects from a preexisting simultaneous echocardiography-catheterization database were selected. Perturbed load-state beats, defined as the first two post-PVC E-waves, and steady-state E-waves, were subjected to conventional and model-based analysis. M, a dimensionless index, defined by the slope of the peak driving-force vs. peak (filling-opposing) resistive-force regression, was determined from steady-state E-waves alone, and from load-perturbed E-waves combined with a matched number of subsequent beats. Despite high degrees of E-wave shape variation, M derived from load-varying, perturbed beats and M derived from steady-state beats alone were indistinguishable. Because the peak driving-force vs. peak resistive-force relation determining M remains highly linear in the extended E-wave shape and load variation regime observed, we conclude that M is a robust LIIDF. (E-mail: [email protected]).
KW - Diastole
KW - Doppler echocardiography
KW - Load-independent index
KW - Mathematical modeling
UR - http://www.scopus.com/inward/record.url?scp=56249131742&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2008.05.002
DO - 10.1016/j.ultrasmedbio.2008.05.002
M3 - Article
C2 - 18692298
AN - SCOPUS:56249131742
SN - 0301-5629
VL - 34
SP - 1901
EP - 1908
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 12
ER -