Transmission of metabolic dysfunction across generations

Kathleen Jaeger, Jessica L. Saben, Kelle H. Moley

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Recent human and animal studies investigating the roles of the genome, epigenome, and environmental cues have identified associations between offspring predisposition to life-long obesity/metabolic disease and epigenetic modifications such as DNA methylation. This review explores the mechanisms by which maternal exposures impair the health of not only the next generation but also potentially future generations of offspring.

Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalPhysiology
Volume32
Issue number1
DOIs
StatePublished - Jan 2017

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