Transmission of metabolic dysfunction across generations

Kathleen Jaeger; Jessica L. Saben; Kelle H. Moley

doi:10.1152/physiol.00017.2016

Transmission of metabolic dysfunction across generations

Kathleen Jaeger, Jessica L. Saben, Kelle H. Moley

Department of Obstetrics & Gynecology

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Recent human and animal studies investigating the roles of the genome, epigenome, and environmental cues have identified associations between offspring predisposition to life-long obesity/metabolic disease and epigenetic modifications such as DNA methylation. This review explores the mechanisms by which maternal exposures impair the health of not only the next generation but also potentially future generations of offspring.

Original language	English
Pages (from-to)	51-59
Number of pages	9
Journal	Physiology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00017.2016
State	Published - Jan 2017

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title = "Transmission of metabolic dysfunction across generations",

abstract = "Recent human and animal studies investigating the roles of the genome, epigenome, and environmental cues have identified associations between offspring predisposition to life-long obesity/metabolic disease and epigenetic modifications such as DNA methylation. This review explores the mechanisms by which maternal exposures impair the health of not only the next generation but also potentially future generations of offspring.",

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Transmission of metabolic dysfunction across generations

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