TY - JOUR
T1 - Translational informatics
T2 - Enabling high-throughput research paradigms
AU - Payne, Philip R.O.
AU - Embi, Peter J.
AU - Sen, Chandan K.
PY - 2009/11
Y1 - 2009/11
N2 - A common thread throughout the clinical and translational research domains is the need to collect, manage, integrate, analyze, and disseminate large-scale, heterogeneous biomedical data sets. However, well-established and broadly adopted theoretical and practical frameworks and models intended to address such needs are conspicuously absent in the published literature or other reputable knowledge sources. Instead, the development and execution of multidisciplinary, clinical, or translational studies are significantly limited by the propagation of "silos" of both data and expertise. Motivated by this fundamental challenge, we report upon the current state and evolution of biomedical informatics as it pertains to the conduct of high-throughput clinical and translational research and will present both a conceptual and practical framework for the design and execution of informatics-enabled studies. The objective of presenting such findings and constructs is to provide the clinical and translational research community with a common frame of reference for discussing and expanding upon such models and methodologies.
AB - A common thread throughout the clinical and translational research domains is the need to collect, manage, integrate, analyze, and disseminate large-scale, heterogeneous biomedical data sets. However, well-established and broadly adopted theoretical and practical frameworks and models intended to address such needs are conspicuously absent in the published literature or other reputable knowledge sources. Instead, the development and execution of multidisciplinary, clinical, or translational studies are significantly limited by the propagation of "silos" of both data and expertise. Motivated by this fundamental challenge, we report upon the current state and evolution of biomedical informatics as it pertains to the conduct of high-throughput clinical and translational research and will present both a conceptual and practical framework for the design and execution of informatics-enabled studies. The objective of presenting such findings and constructs is to provide the clinical and translational research community with a common frame of reference for discussing and expanding upon such models and methodologies.
KW - Biomedical research
UR - http://www.scopus.com/inward/record.url?scp=72949114284&partnerID=8YFLogxK
U2 - 10.1152/physiolgenomics.00050.2009
DO - 10.1152/physiolgenomics.00050.2009
M3 - Review article
C2 - 19737991
AN - SCOPUS:72949114284
SN - 1094-8341
VL - 39
SP - 131
EP - 140
JO - Physiological genomics
JF - Physiological genomics
IS - 3
ER -