TY - JOUR
T1 - Transimpedance Mode CMOS Microelectrode Array For In-Vitro Neuronal Activity Recording
AU - Wegman, Jacob S.
AU - Dwarka, Amar
AU - Holzer, Matthew
AU - Lye, Whye Kei
AU - Reed, Michael L.
AU - Herzog, Erik
AU - Blalock, Travis N.
PY - 2003
Y1 - 2003
N2 - A CMOS integrated microelectrode array (IMA) utilizing a low-inpedance transimpedance input has been developed. The design uses a three-stage amplifier, including a transimpedance input stage, buffer, and multiplexor. The input stage presents a low impedance which provides bias for the neural input and maximizes the current transfer into the circuit. The amplifiers are replicated in an 8×8 array, enabling measurement of a network of 64 neurons invitro. The chip was post-processed to provide a bio-compatible gold interface between the electrodes and the neurons. Simulations and experimental results demonstrate the functionality of the new design. Additional measurements are underway to provide experimental confirmation of the system with in-vitro neurons.
AB - A CMOS integrated microelectrode array (IMA) utilizing a low-inpedance transimpedance input has been developed. The design uses a three-stage amplifier, including a transimpedance input stage, buffer, and multiplexor. The input stage presents a low impedance which provides bias for the neural input and maximizes the current transfer into the circuit. The amplifiers are replicated in an 8×8 array, enabling measurement of a network of 64 neurons invitro. The chip was post-processed to provide a bio-compatible gold interface between the electrodes and the neurons. Simulations and experimental results demonstrate the functionality of the new design. Additional measurements are underway to provide experimental confirmation of the system with in-vitro neurons.
UR - http://www.scopus.com/inward/record.url?scp=1542334493&partnerID=8YFLogxK
U2 - 10.1557/proc-773-n6.2
DO - 10.1557/proc-773-n6.2
M3 - Conference article
AN - SCOPUS:1542334493
SN - 0272-9172
VL - 773
SP - 143
EP - 148
JO - Materials Research Society Symposium Proceedings
JF - Materials Research Society Symposium Proceedings
T2 - Biomicroelectromechanical Systems (BioMEMS)
Y2 - 22 April 2003 through 25 April 2003
ER -