A CMOS integrated microelectrode array (IMA) utilizing a low-inpedance transimpedance input has been developed. The design uses a three-stage amplifier, including a transimpedance input stage, buffer, and multiplexor. The input stage presents a low impedance which provides bias for the neural input and maximizes the current transfer into the circuit. The amplifiers are replicated in an 8×8 array, enabling measurement of a network of 64 neurons invitro. The chip was post-processed to provide a bio-compatible gold interface between the electrodes and the neurons. Simulations and experimental results demonstrate the functionality of the new design. Additional measurements are underway to provide experimental confirmation of the system with in-vitro neurons.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalMaterials Research Society Symposium Proceedings
StatePublished - 2003
EventBiomicroelectromechanical Systems (BioMEMS) - San Francisco, CA, United States
Duration: Apr 22 2003Apr 25 2003


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