Transient alteration of the blood-brain barrier: Effect of hypertonic solutions administered via carotid artery injection

Rebecca K. Studer, Dennis M. Welch, Barry A. Siegel

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Transient increases in the permeability of the blood-brain barrier were observed after the intracarotid administration of hypertonic solutions in rats. The alterations were similar to those described by other investigators, but occurred after less-severe cerebral vascular insults. More subtle changes in permeability were identified using sodium-22, than with conventional techniques employing labeled proteins.

Original languageEnglish
Pages (from-to)266-273
Number of pages8
JournalExperimental Neurology
Volume44
Issue number2
DOIs
StatePublished - Aug 1974

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