TY - JOUR
T1 - Transient alteration of the blood-brain barrier
T2 - Effect of hypertonic solutions administered via carotid artery injection
AU - Studer, Rebecca K.
AU - Welch, Dennis M.
AU - Siegel, Barry A.
N1 - Funding Information:
During an evaluation of distribution spaces of several radionuclide tracers in the rat brain after cerebral microembolization, we noted that at short intervals after carotid artery injection of SO-pm microspheres suspended in 0.1 ml 77% sucrose, the distribution spaces did not increase with increasing cerebral edema as expected. On the contrary, the largest spaces were seen 30 min after embolization, at which time only minimal cerebral edema was present. The microspheres were injected in a hyperos-molar solution; however, based on the existing data on reversible opening of the blood-brain barrier after topical or intravascular application of such solutions (14-16)) the osmotic “dose” in our experiments seemed to be well below the levels reported to induce such alterations. Thus, to determine whether the changes we observed were due to an acute, transient response to microembolism, the injection procedure itself, or the composition 1 Supported in part by N.I.H. Grant ROl-HLlZZ37, Training Grant TOl-GM01747, and U.S. Atomic Energy Commission Contract AEC No. CO-1653-148. We acknowledge the technical assistance of Michael Breining, Stephen Coates, and Joan Primeau. Reprint requests to: Dr. Barry A. Siegel, 510 S. Kingshighway Blvd., St. Louis. MO. 63110.
PY - 1974/8
Y1 - 1974/8
N2 - Transient increases in the permeability of the blood-brain barrier were observed after the intracarotid administration of hypertonic solutions in rats. The alterations were similar to those described by other investigators, but occurred after less-severe cerebral vascular insults. More subtle changes in permeability were identified using sodium-22, than with conventional techniques employing labeled proteins.
AB - Transient increases in the permeability of the blood-brain barrier were observed after the intracarotid administration of hypertonic solutions in rats. The alterations were similar to those described by other investigators, but occurred after less-severe cerebral vascular insults. More subtle changes in permeability were identified using sodium-22, than with conventional techniques employing labeled proteins.
UR - http://www.scopus.com/inward/record.url?scp=0016140028&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(74)90064-8
DO - 10.1016/0014-4886(74)90064-8
M3 - Article
C2 - 4843261
AN - SCOPUS:0016140028
SN - 0014-4886
VL - 44
SP - 266
EP - 273
JO - Experimental Neurology
JF - Experimental Neurology
IS - 2
ER -