Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

Michal Pravenec, Vladimir Landa, Vaclav Zidek, Alena Musilova, Vladimir Kren, Ludmila Kazdova, Timothy J. Aitman, Anne M. Glazier, Azeddine Ibrahimi, Nada A. Abumrad, Nianning Qi, Jia Ming Wang, Elizabeth M. St. Lezin, Theodore W. Kurtz

Research output: Contribution to journalArticlepeer-review

164 Scopus citations

Abstract

Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.

Original languageEnglish
Pages (from-to)156-158
Number of pages3
JournalNature Genetics
Volume27
Issue number2
DOIs
StatePublished - 2001

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