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Transgenic Gαq overexpression induces cardiac contractile failure in mice
Drew D. D'Angelo
, Yoshihito Sakata
, John N. Lorenz
, Gregory P. Boivin
, Richard A. Walsh
, Stephen B. Liggett
, Gerald W. Dorn
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Institute of Clinical and Translational Sciences (ICTS)
Department of Medicine
DBBS - Molecular Cell Biology
DBBS - Human and Statistical Genetics
DBBS - Molecular Genetics and Genomics
Research output
:
Contribution to journal
›
Article
›
peer-review
552
Scopus citations
Overview
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Keyphrases
Overexpression
100%
Transgenic
100%
Hypertrophy
50%
Cardiac Hypertrophy
50%
Myosin Heavy Chain (MyHC)
50%
Mitogen-activated Protein Kinase
25%
Cell Signaling
25%
Protein Kinase
25%
Signaling Pathway
25%
Transgenic Mice
25%
Fractional Shortening
25%
Heart Failure
25%
Physiologic
25%
Actin
25%
In(III)
25%
Echocardiography
25%
4-fold
25%
Common Mechanisms
25%
Contractility
25%
Dobutamine
25%
Adrenergic Receptors
25%
Adrenergic Agonist
25%
Contractile Response
25%
Pulmonary Congestion
25%
Hemodynamic Assessment
25%
Heart Weight
25%
Cardiac Decompensation
25%
Cardiac Hemodynamics
25%
Human Heart Failure
25%
Adenylyl Cyclase Activity
25%
Force-frequency Response
25%
Myocyte Size
25%
Biventricular Failure
25%
Starling
25%
Biochemistry, Genetics and Molecular Biology
Transgenics
100%
Heavy Meromyosin
100%
Mitogen-Activated Protein Kinase
50%
Wild Type
50%
Transgenic Mouse
50%
Promoter Region
50%
Agonist
50%
Protein Kinase C
50%
Actin
50%
Adenylate Cyclase
50%
Muscle Contractility
50%
Adrenergic Receptor
50%
Heart Weight
50%
Heart Hemodynamics
50%
Starling
50%
Dobutamine
50%
Medicine and Dentistry
Congestive Heart Failure
100%
Ventricular Hypertrophy
66%
Heavy Meromyosin
66%
Promoter Region
33%
Transgenic Mouse
33%
Echocardiography
33%
Actin
33%
Protein Kinase C
33%
Adenylate Cyclase
33%
Mitogen-Activated Protein Kinase
33%
Muscle Contractility
33%
Cell Signaling Pathway
33%
Dobutamine
33%
Adrenergic Receptor
33%
Lung Congestion
33%
Sympathomimetic Drug
33%
Heart Hemodynamics
33%
Pharmacology, Toxicology and Pharmaceutical Science
Congestive Heart Failure
100%
Myosin Heavy Chain
66%
Heart Ventricle Hypertrophy
66%
Transgenic Mouse
33%
Mitogen Activated Protein Kinase
33%
Actin
33%
Protein Kinase C
33%
Dobutamine
33%
Adrenergic Receptor
33%
Adenylate Cyclase
33%
Lung Congestion
33%
Adrenergic Receptor Stimulating Agent
33%
Starling
33%