TY - JOUR
T1 - Transgenerational epigenetic inheritance
T2 - from phenomena to molecular mechanisms
AU - Liberman, Noa
AU - Wang, Simon Yuan
AU - Greer, Eric Lieberman
N1 - Funding Information:
We thank E. Pollina and J. Lieberman for critically reading the manuscript. S.Y.W. was supported by a Croucher Foundation fellowship. This work was supported by the National Institutes of Health (grant numbers R00AG043550 , R21HG010066 , and DP2AG055947 ).
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - Inherited information not encoded in the DNA sequence can regulate a variety of complex phenotypes. However, how this epigenetic information escapes the typical epigenetic erasure that occurs upon fertilization and how it regulates behavior is still unclear. Here we review recent examples of brain related transgenerational epigenetic inheritance and delineate potential molecular mechanisms that could regulate how non-genetic information could be transmitted.
AB - Inherited information not encoded in the DNA sequence can regulate a variety of complex phenotypes. However, how this epigenetic information escapes the typical epigenetic erasure that occurs upon fertilization and how it regulates behavior is still unclear. Here we review recent examples of brain related transgenerational epigenetic inheritance and delineate potential molecular mechanisms that could regulate how non-genetic information could be transmitted.
UR - http://www.scopus.com/inward/record.url?scp=85073562096&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2019.09.012
DO - 10.1016/j.conb.2019.09.012
M3 - Review article
C2 - 31634674
AN - SCOPUS:85073562096
SN - 0959-4388
VL - 59
SP - 189
EP - 206
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -