Transganglionic response of GAP-43 in the gracile nucleus to sciatic nerve injury in young and aged rats

Shinji Ohara, Lucie N. Beaudet, Robert E. Schmidt

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Sciatic nerve axotomy induces the transganglionic expression of the growth associated protein GAP-43 and neuropeptide Y (NPY) in lumbar DRG projections to the gracile nucleus. Four weeks after axotomy young animals had developed delicate GAP-43 and NPY-immunoreactive axonal sprouts in the gracile nuclei; however, an identical insult to aged (14-26 months) animals resulted in the labeling of swollen dystrophic elements and fewer delicate axonal sprouts. Unilateral sciatic transection in young rats with subsequent frustration of regeneration for 8 months resulted in ipsilateral gracile neuroaxonal dystrophy as assessed by ultrastructural, immunohistologic and quantitative morphometric techniques.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalBrain Research
Volume705
Issue number1-2
DOIs
StatePublished - Dec 24 1995

Keywords

  • Axotomy
  • Dorsal root ganglia
  • GAP-43
  • Neuroaxonal dystrophy

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