Transfusion in the mechanically ventilated patient

Nicole P. Juffermans, Cécile Aubron, Jacques Duranteau, Alexander P.J. Vlaar, Daryl J. Kor, Jennifer A. Muszynski, Philip C. Spinella, Jean Louis Vincent

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Red blood cell transfusions are a frequent intervention in critically ill patients, including in those who are receiving mechanical ventilation. Both these interventions can impact negatively on lung function with risks of transfusion-related acute lung injury (TRALI) and other forms of acute respiratory distress syndrome (ARDS). The interactions between transfusion, mechanical ventilation, TRALI and ARDS are complex and other patient-related (e.g., presence of sepsis or shock, disease severity, and hypervolemia) or blood product-related (e.g., presence of antibodies or biologically active mediators) factors also play a role. We propose several strategies targeted at these factors that may help limit the risks of associated lung injury in critically ill patients being considered for transfusion.

Original languageEnglish
Pages (from-to)2450-2457
Number of pages8
JournalIntensive care medicine
Issue number12
StatePublished - Dec 2020


  • Acute respiratory distress syndrome
  • Anemia
  • Hypervolemia
  • Inflammatory response
  • Oxygen delivery
  • Transfusion-associated circulatory overload
  • Transfusion-related acute lung injury


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