Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor

Steven F. Josephs; Ratner Lee; Michael F. Clarke; Eric H. Westin; Marvin S. Reitz; Flossie Wong-Staal

doi:10.1126/science.6740330

Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor

Steven F. Josephs, Ratner Lee, Michael F. Clarke, Eric H. Westin, Marvin S. Reitz, Flossie Wong-Staal

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.

Original language	English
Pages (from-to)	636-639
Number of pages	4
Journal	Science
Volume	225
Issue number	4662
DOIs	https://doi.org/10.1126/science.6740330
State	Published - 1984

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title = "Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor",

abstract = "The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.",

author = "Josephs, {Steven F.} and Ratner Lee and Clarke, {Michael F.} and Westin, {Eric H.} and Reitz, {Marvin S.} and Flossie Wong-Staal",

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AU - Josephs, Steven F.

AU - Lee, Ratner

AU - Clarke, Michael F.

AU - Westin, Eric H.

AU - Reitz, Marvin S.

AU - Wong-Staal, Flossie

PY - 1984

Y1 - 1984

N2 - The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.

AB - The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.

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DO - 10.1126/science.6740330

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Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor

Abstract

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