Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor

Steven F. Josephs, Ratner Lee, Michael F. Clarke, Eric H. Westin, Marvin S. Reitz, Flossie Wong-Staal

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.

Original languageEnglish
Pages (from-to)636-639
Number of pages4
JournalScience
Volume225
Issue number4662
DOIs
StatePublished - 1984

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