Transforming growth factor beta in cardiovascular development and function

Mohamad Azhar; Jo El J. Schultz; Ingrid Grupp; Gerald W. Dorn; Pierre Meneton; Daniel G.M. Molin; Adriana C. Gittenberger-de Groot; Thomas Doetschman

doi:10.1016/S1359-6101(03)00044-3

Transforming growth factor beta in cardiovascular development and function

Mohamad Azhar, Jo El J. Schultz, Ingrid Grupp, Gerald W. Dorn, Pierre Meneton, Daniel G.M. Molin, Adriana C. Gittenberger-de Groot, Thomas Doetschman

Research output: Contribution to journal › Review article › peer-review

198 Scopus citations

Abstract

Transforming growth factor betas (TGFβs) are pleiotropic cytokines involved in many biological processes. Genetic engineering and tissue explanation studies have revealed specific non-overlapping roles for TGFβ ligands and their signaling molecules in development and in normal function of the cardiovascular system in the adult. In the embryo, TGFβs appear to be involved in epithelial-mesenchymal transformations (EMT) during endocardial cushion formation, and in epicardial epithelial-mesenchymal transformations essential for coronary vasculature, ventricular myocardial development and compaction. In the adult, TGFβs are involved in cardiac hypertrophy, vascular remodeling and regulation of the renal renin-angiotensin system. The evidence for TGFβ activities during cardiovascular development and physiologic function will be given and areas which need further investigation will be discussed.

Original language	English
Pages (from-to)	391-407
Number of pages	17
Journal	Cytokine and Growth Factor Reviews
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/S1359-6101(03)00044-3
State	Published - Oct 2003

Keywords

Development
Heart
Physiology
TGFβ
Vasculature

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10.1016/S1359-6101(03)00044-3

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title = "Transforming growth factor beta in cardiovascular development and function",

abstract = "Transforming growth factor betas (TGFβs) are pleiotropic cytokines involved in many biological processes. Genetic engineering and tissue explanation studies have revealed specific non-overlapping roles for TGFβ ligands and their signaling molecules in development and in normal function of the cardiovascular system in the adult. In the embryo, TGFβs appear to be involved in epithelial-mesenchymal transformations (EMT) during endocardial cushion formation, and in epicardial epithelial-mesenchymal transformations essential for coronary vasculature, ventricular myocardial development and compaction. In the adult, TGFβs are involved in cardiac hypertrophy, vascular remodeling and regulation of the renal renin-angiotensin system. The evidence for TGFβ activities during cardiovascular development and physiologic function will be given and areas which need further investigation will be discussed.",

keywords = "Development, Heart, Physiology, TGFβ, Vasculature",

author = "Mohamad Azhar and Schultz, {Jo El J.} and Ingrid Grupp and Dorn, {Gerald W.} and Pierre Meneton and Molin, {Daniel G.M.} and {Gittenberger-de Groot}, {Adriana C.} and Thomas Doetschman",

note = "Funding Information: Grant support for the studies presented here: NIH grants HD26471, HL70174, HL58511, ES06096 to TD; INSERM and Association Claude Bernard to PM; VA Merit Review to GWD; NHS: ECCARD to ACG.",

year = "2003",

month = oct,

doi = "10.1016/S1359-6101(03)00044-3",

language = "English",

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journal = "Cytokine and Growth Factor Reviews",

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AU - Azhar, Mohamad

AU - Schultz, Jo El J.

AU - Grupp, Ingrid

AU - Dorn, Gerald W.

AU - Meneton, Pierre

AU - Molin, Daniel G.M.

AU - Gittenberger-de Groot, Adriana C.

AU - Doetschman, Thomas

N1 - Funding Information: Grant support for the studies presented here: NIH grants HD26471, HL70174, HL58511, ES06096 to TD; INSERM and Association Claude Bernard to PM; VA Merit Review to GWD; NHS: ECCARD to ACG.

PY - 2003/10

Y1 - 2003/10

N2 - Transforming growth factor betas (TGFβs) are pleiotropic cytokines involved in many biological processes. Genetic engineering and tissue explanation studies have revealed specific non-overlapping roles for TGFβ ligands and their signaling molecules in development and in normal function of the cardiovascular system in the adult. In the embryo, TGFβs appear to be involved in epithelial-mesenchymal transformations (EMT) during endocardial cushion formation, and in epicardial epithelial-mesenchymal transformations essential for coronary vasculature, ventricular myocardial development and compaction. In the adult, TGFβs are involved in cardiac hypertrophy, vascular remodeling and regulation of the renal renin-angiotensin system. The evidence for TGFβ activities during cardiovascular development and physiologic function will be given and areas which need further investigation will be discussed.

AB - Transforming growth factor betas (TGFβs) are pleiotropic cytokines involved in many biological processes. Genetic engineering and tissue explanation studies have revealed specific non-overlapping roles for TGFβ ligands and their signaling molecules in development and in normal function of the cardiovascular system in the adult. In the embryo, TGFβs appear to be involved in epithelial-mesenchymal transformations (EMT) during endocardial cushion formation, and in epicardial epithelial-mesenchymal transformations essential for coronary vasculature, ventricular myocardial development and compaction. In the adult, TGFβs are involved in cardiac hypertrophy, vascular remodeling and regulation of the renal renin-angiotensin system. The evidence for TGFβ activities during cardiovascular development and physiologic function will be given and areas which need further investigation will be discussed.

KW - Development

KW - Heart

KW - Physiology

KW - TGFβ

KW - Vasculature

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DO - 10.1016/S1359-6101(03)00044-3

M3 - Review article

C2 - 12948523

AN - SCOPUS:0042876796

SN - 1359-6101

VL - 14

SP - 391

EP - 407

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 5

ER -

Transforming growth factor beta in cardiovascular development and function

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