@article{874a5a0b1e7541e89a0fc603f46de9be,
title = "Transforming Growth Factor-β in the Acute Kidney Injury to Chronic Kidney Disease Transition",
abstract = "Transforming growth factor-β (TGF-β) is a key profibrotic growth factor that is activated in acute kidney injury (AKI) and associated with cellular responses that lead to the development of chronic kidney disease (CKD). The persistently injured, de-differentiated tubular epithelial cell is an important mediator of the transition from AKI to CKD. TGF-β signaling may perpetuate proximal tubule injury through de-differentiation, cell cycle arrest, and increased susceptibility to apoptosis. In addition, TGF-β signaling promotes macrophage chemotaxis, endothelial injury, and myofibroblast differentiation after AKI. Future studies that block TGF-β signaling after cessation of AKI are needed to better define its role in the progression of acute to chronic renal injury.",
keywords = "Acute renal injury, Chronic renal disease, Epithelial cells",
author = "Gewin, {Leslie S.}",
note = "Funding Information: Contribution from the AKI and CRRT 2019 Symposium at the 24th International Conference on Advances in Critical Care Nephrology, Manchester Grand Hyatt, San Diego, CA, USA, February 26 – March 1, 2019. This symposium was supported in part by the NIDDK funded University of Alabama at Birmingham-University of California San Diego O{\textquoteright}Brien Center for Acute Kidney Injury Research (P30DK079337). Funding Information: Contribution from the AKI and CRRT 2019 Symposium at the 24th International Conference on Advances in Critical Care Nephrology, Manchester Grand Hyatt, San Diego, CA, USA, February 26 March 1, 2019. This symposium was supported in part by the NIDDK funded University of Alabama at Birmingham-University of California San Diego O'Brien Center for Acute Kidney Injury Research (P30DK079337). Publisher Copyright: {\textcopyright} 2019 S. Karger AG, Basel. All rights reserved.",
year = "2019",
month = oct,
day = "1",
doi = "10.1159/000500093",
language = "English",
volume = "143",
pages = "154--157",
journal = "Nephron",
issn = "1660-8151",
number = "3",
}