Transductional and transcriptional targeting of adenovirus for clinical applications

J. N. Glasgow, G. J. Bauerschmitz, D. T. Curiel, Akseli Hemminki

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

Adenovirus (Ad) targeting is a novel approach for the design and administration of therapeutic agents wherein the agent is rationally designed to localize and restrict transgene expression to the site of disease in a self-directed manner, usually via exploitation of unique biophysical and genetic properties specific to the diseased tissue. The ablation of promiscuous native Ad tropism coupled with active targeting modalities has demonstrated that innate gene delivery efficiency may be retained while circumventing Ad dependence on its primary cellular receptor, the coxsackie and adenovirus receptor (CAR), to achieve CAR-independent vector tropism. Herein, we describe advances in Ad targeting that are predicated not only on fundamental understanding of vector/cell interplay, but also on the specific transcriptional profiles of target tissues. Further, targeting is discussed in the context of improving the safety and efficacy of clinical approaches utilizing adenoviral vectors and replication competent oncolytic agents. In summary, existing results suggest a critical linkage between targeted agents and increases in therapeutic utility.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalCurrent gene therapy
Volume4
Issue number1
DOIs
StatePublished - Mar 2004

Keywords

  • Adenovirus
  • Gene therapy
  • Oncolytic virus
  • Review
  • Vector targeting

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