Transcriptome evaluation of the relation between body mass index and prostate cancer outcomes

Hyun Kim, Ingrid Kalchman, María Santiago-Jiménez, Jonathan Lehrer, Jenny Guo, Gretchen Hermann, Kosj Yamoah, Mohammed Alshalalfa, Huei Chung Huang, Ashley E. Ross, Edward M. Schaeffer, Elai Davicioni, Nicholas Erho, Kasra Yousefi, Robert B. Den

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

BACKGROUND: Large epidemiological studies indicate that an increased body mass index (BMI) is associated with increased prostate cancer (PCa) mortality. Data indicate that there is no association between elevated metabolic pathway proteins and PCa mortality. There are no published studies evaluating the relation between BMI and metabolic pathways with respect to PCa outcomes with a genomics approach. METHODS: The Decipher Genomic Resource Information Database was queried for patients who had undergone prostatectomy and had BMI information available. These patients came from Thomas Jefferson University (TJU) and Johns Hopkins Medical Institution (JHMI); the latter provided 2 cohorts (I and II). A high-BMI group (≥30 kg/m2) and a low-BMI group (<25 kg/m2) were identified, and genomic data were interrogated for differentially expressed genes with an interquartile range filter and a Wilcoxon test. P values were adjusted for multiple testing with the Benjamini-Hochberg false-discovery rate method. RESULTS: A total of 477 patients with a median follow-up of 108 months had BMI information available. Two genes were found to interact with BMI in both the JHMI I cohort and the TJU cohort, but there was no statistical significance after adjustments for multiple comparisons. Aberrant metabolic gene expression was significantly correlated with distant metastases (P <.05). No relation was found between BMI and metastases or overall survival (both P values >.05). CONCLUSIONS: In a genomic analysis of prostatectomy specimens, metabolic gene expression, but not BMI, was associated with PCa metastases. Cancer 2017;123:2240–2247.

Original languageEnglish
Pages (from-to)2240-2247
Number of pages8
JournalCancer
Volume123
Issue number12
DOIs
StatePublished - Jun 15 2017
Externally publishedYes

Keywords

  • body mass index
  • genomics
  • metabolic gene expression
  • prostate cancer
  • transcriptome

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