TY - JOUR
T1 - Transcriptional regulation of memory B cell differentiation
AU - Laidlaw, Brian J.
AU - Cyster, Jason G.
N1 - Publisher Copyright:
© 2020, Springer Nature Limited.
PY - 2021/4
Y1 - 2021/4
N2 - Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to develop vaccines that induce broadly protective MBCs to rapidly mutating pathogens have not yet been successful. Better understanding of the signals regulating MBC development and function are essential to overcome current challenges hindering successful vaccine development. Here, we discuss recent advancements regarding the signals and transcription factors regulating germinal centre-derived MBC development and function.
AB - Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to develop vaccines that induce broadly protective MBCs to rapidly mutating pathogens have not yet been successful. Better understanding of the signals regulating MBC development and function are essential to overcome current challenges hindering successful vaccine development. Here, we discuss recent advancements regarding the signals and transcription factors regulating germinal centre-derived MBC development and function.
UR - http://www.scopus.com/inward/record.url?scp=85092107508&partnerID=8YFLogxK
U2 - 10.1038/s41577-020-00446-2
DO - 10.1038/s41577-020-00446-2
M3 - Review article
C2 - 33024284
AN - SCOPUS:85092107508
SN - 1474-1733
VL - 21
SP - 209
EP - 220
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 4
ER -