Transcriptional regulation of memory B cell differentiation

Brian J. Laidlaw, Jason G. Cyster

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to develop vaccines that induce broadly protective MBCs to rapidly mutating pathogens have not yet been successful. Better understanding of the signals regulating MBC development and function are essential to overcome current challenges hindering successful vaccine development. Here, we discuss recent advancements regarding the signals and transcription factors regulating germinal centre-derived MBC development and function.

Original languageEnglish
Pages (from-to)209-220
Number of pages12
JournalNature Reviews Immunology
Volume21
Issue number4
DOIs
StatePublished - Apr 2021

Fingerprint

Dive into the research topics of 'Transcriptional regulation of memory B cell differentiation'. Together they form a unique fingerprint.

Cite this