Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

Michelle L. Robinette, Anja Fuchs, Victor S. Cortez, Jacob S. Lee, Yaming Wang, Scott K. Durum, Susan Gilfillan, Marco Colonna

Research output: Contribution to journalArticlepeer-review

447 Scopus citations

Abstract

The recognized diversity of innate lymphoid cells (ILCs) is rapidly expanding. Three ILC classes have emerged, ILC1, ILC2 and ILC3, with ILC1 and ILC3 including several subsets. The classification of some subsets is unclear, and it remains controversial whether natural killer (NK) cells and ILC1 cells are distinct cell types. To address these issues, we analyzed gene expression in ILCs and NK cells from mouse small intestine, spleen and liver, as part of the Immunological Genome Project. The results showed unique gene-expression patterns for some ILCs and overlapping patterns for ILC1 cells and NK cells, whereas other ILC subsets remained indistinguishable. We identified a transcriptional program shared by small intestine ILCs and a core ILC signature. We revealed and discuss transcripts that suggest previously unknown functions and developmental paths for ILCs.

Original languageEnglish
Pages (from-to)306-317
Number of pages12
JournalNature immunology
Volume16
Issue number3
DOIs
StatePublished - Feb 17 2015

Fingerprint

Dive into the research topics of 'Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets'. Together they form a unique fingerprint.

Cite this