TY - CHAP
T1 - Transcriptional Control of Dendritic Cell Development
AU - Murphy, Kenneth M.
N1 - Funding Information:
This work was supported by the Howard Hughes Medical Institute and a grant from the Alvin J. Siteman Cancer Center, which is supported in part by National Cancer Institute Cancer Center Support Grant #P30 CA91842. The author has no conflicting financial interests.
PY - 2013
Y1 - 2013
N2 - Dendritic cells (DCs) drive both adaptive and innate immunity. Recent findings support the notion that distinct subsets of classical DCs favor alternative modules of immunity, acting on innate lymphoid-like cells (ILCs) and T cells similarly to promote either ILC1/Th1/CTL- or ILC3/Th17-type responses. Coordination between DC subsets and their favored immune module might imply that the genetic programs for DC diversification preceded the emergence of recombination-activating gene-dependent adaptive immunity and operate initially in coordinating ILC repertoires for appropriate responses against pathogens. Consequently, understanding the molecular basis of DC developmental and diversification is important for an underlying appreciation of immune regulation. Currently, the basis for DC development into the recognized subsets/lineages is only partially understood, based on the requirements for several transcription factors including PU.1, Bcl11a, Irf8, E2-2, Id2, Irf4, Irf8, Batf3, and other BATF family members. This chapter will briefly review recent transcriptional aspects of DC development and function and then highlight some currently unresolved questions.
AB - Dendritic cells (DCs) drive both adaptive and innate immunity. Recent findings support the notion that distinct subsets of classical DCs favor alternative modules of immunity, acting on innate lymphoid-like cells (ILCs) and T cells similarly to promote either ILC1/Th1/CTL- or ILC3/Th17-type responses. Coordination between DC subsets and their favored immune module might imply that the genetic programs for DC diversification preceded the emergence of recombination-activating gene-dependent adaptive immunity and operate initially in coordinating ILC repertoires for appropriate responses against pathogens. Consequently, understanding the molecular basis of DC developmental and diversification is important for an underlying appreciation of immune regulation. Currently, the basis for DC development into the recognized subsets/lineages is only partially understood, based on the requirements for several transcription factors including PU.1, Bcl11a, Irf8, E2-2, Id2, Irf4, Irf8, Batf3, and other BATF family members. This chapter will briefly review recent transcriptional aspects of DC development and function and then highlight some currently unresolved questions.
KW - Common dendritic progenitor
KW - Dendritic cell
KW - Lineage commitment
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=84884380781&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-417028-5.00009-0
DO - 10.1016/B978-0-12-417028-5.00009-0
M3 - Chapter
C2 - 24070387
AN - SCOPUS:84884380781
T3 - Advances in Immunology
SP - 239
EP - 267
BT - Advances in Immunology
PB - Academic Press Inc.
ER -