Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development

S. Kiiveri; J. Liu; M. Westerholm-Ormio; N. Narita; D. B. Wilson; R. Voutilainen; M. Heikinheimo

doi:10.1081/ERC-120016980

Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development

S. Kiiveri
, J. Liu
, M. Westerholm-Ormio
, N. Narita
, D. B. Wilson
, R. Voutilainen
, M. Heikinheimo

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Our earlier work implicates transcription factors GATA-4 and GATA-6 in the murine adrenal. We have now studied their expression during mouse and human adrenal development in detail. GATA-4 and GATA-6 mRNAs are readily detectable from embryonic day 15 in mouse and gestational week 19 in human adrenal cortex. In postnatal adrenal, GATA-4 expression is down-regulated, whereas GATA-6 mRNA and protein continue to be abundantly present. In a human adrenocortical cell line NCI-H295R, GATA-6 mRNA is up-regulated by cAMP. This cell line does not express GATA-4. Our findings suggest that GATA-6 expression is hormonally controlled, and required throughout adrenal development from fetal to adult age. GATA-4, on the other hand, may serve a role in fetal adrenal gene regulation.

Original language	English
Pages (from-to)	647-650
Number of pages	4
Journal	Endocrine Research
Volume	28
Issue number	4
DOIs	https://doi.org/10.1081/ERC-120016980
State	Published - 2002

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title = "Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development",

abstract = "Our earlier work implicates transcription factors GATA-4 and GATA-6 in the murine adrenal. We have now studied their expression during mouse and human adrenal development in detail. GATA-4 and GATA-6 mRNAs are readily detectable from embryonic day 15 in mouse and gestational week 19 in human adrenal cortex. In postnatal adrenal, GATA-4 expression is down-regulated, whereas GATA-6 mRNA and protein continue to be abundantly present. In a human adrenocortical cell line NCI-H295R, GATA-6 mRNA is up-regulated by cAMP. This cell line does not express GATA-4. Our findings suggest that GATA-6 expression is hormonally controlled, and required throughout adrenal development from fetal to adult age. GATA-4, on the other hand, may serve a role in fetal adrenal gene regulation.",

author = "S. Kiiveri and J. Liu and M. Westerholm-Ormio and N. Narita and Wilson, \{D. B.\} and R. Voutilainen and M. Heikinheimo",

note = "Funding Information: This work was supported by the Finnish Pediatric Research Foundation, the University of Helsinki, the University Central Hospital in Helsinki, the Academy of Finland, the Juselius Foundation, and Kuopio University Hospital.",

year = "2002",

doi = "10.1081/ERC-120016980",

language = "English",

volume = "28",

pages = "647--650",

journal = "Endocrine Research",

issn = "0743-5800",

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TY - JOUR

T1 - Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development

AU - Kiiveri, S.

AU - Liu, J.

AU - Westerholm-Ormio, M.

AU - Narita, N.

AU - Wilson, D. B.

AU - Voutilainen, R.

AU - Heikinheimo, M.

N1 - Funding Information: This work was supported by the Finnish Pediatric Research Foundation, the University of Helsinki, the University Central Hospital in Helsinki, the Academy of Finland, the Juselius Foundation, and Kuopio University Hospital.

PY - 2002

Y1 - 2002

N2 - Our earlier work implicates transcription factors GATA-4 and GATA-6 in the murine adrenal. We have now studied their expression during mouse and human adrenal development in detail. GATA-4 and GATA-6 mRNAs are readily detectable from embryonic day 15 in mouse and gestational week 19 in human adrenal cortex. In postnatal adrenal, GATA-4 expression is down-regulated, whereas GATA-6 mRNA and protein continue to be abundantly present. In a human adrenocortical cell line NCI-H295R, GATA-6 mRNA is up-regulated by cAMP. This cell line does not express GATA-4. Our findings suggest that GATA-6 expression is hormonally controlled, and required throughout adrenal development from fetal to adult age. GATA-4, on the other hand, may serve a role in fetal adrenal gene regulation.

AB - Our earlier work implicates transcription factors GATA-4 and GATA-6 in the murine adrenal. We have now studied their expression during mouse and human adrenal development in detail. GATA-4 and GATA-6 mRNAs are readily detectable from embryonic day 15 in mouse and gestational week 19 in human adrenal cortex. In postnatal adrenal, GATA-4 expression is down-regulated, whereas GATA-6 mRNA and protein continue to be abundantly present. In a human adrenocortical cell line NCI-H295R, GATA-6 mRNA is up-regulated by cAMP. This cell line does not express GATA-4. Our findings suggest that GATA-6 expression is hormonally controlled, and required throughout adrenal development from fetal to adult age. GATA-4, on the other hand, may serve a role in fetal adrenal gene regulation.

UR - https://www.scopus.com/pages/publications/12244259069

U2 - 10.1081/ERC-120016980

DO - 10.1081/ERC-120016980

M3 - Article

C2 - 12530677

AN - SCOPUS:12244259069

SN - 0743-5800

VL - 28

SP - 647

EP - 650

JO - Endocrine Research

JF - Endocrine Research

IS - 4

ER -

Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development

Abstract

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