TY - JOUR
T1 - Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development
AU - Kiiveri, S.
AU - Liu, J.
AU - Westerholm-Ormio, M.
AU - Narita, N.
AU - Wilson, D. B.
AU - Voutilainen, R.
AU - Heikinheimo, M.
N1 - Funding Information:
This work was supported by the Finnish Pediatric Research Foundation, the University of Helsinki, the University Central Hospital in Helsinki, the Academy of Finland, the Juselius Foundation, and Kuopio University Hospital.
PY - 2002
Y1 - 2002
N2 - Our earlier work implicates transcription factors GATA-4 and GATA-6 in the murine adrenal. We have now studied their expression during mouse and human adrenal development in detail. GATA-4 and GATA-6 mRNAs are readily detectable from embryonic day 15 in mouse and gestational week 19 in human adrenal cortex. In postnatal adrenal, GATA-4 expression is down-regulated, whereas GATA-6 mRNA and protein continue to be abundantly present. In a human adrenocortical cell line NCI-H295R, GATA-6 mRNA is up-regulated by cAMP. This cell line does not express GATA-4. Our findings suggest that GATA-6 expression is hormonally controlled, and required throughout adrenal development from fetal to adult age. GATA-4, on the other hand, may serve a role in fetal adrenal gene regulation.
AB - Our earlier work implicates transcription factors GATA-4 and GATA-6 in the murine adrenal. We have now studied their expression during mouse and human adrenal development in detail. GATA-4 and GATA-6 mRNAs are readily detectable from embryonic day 15 in mouse and gestational week 19 in human adrenal cortex. In postnatal adrenal, GATA-4 expression is down-regulated, whereas GATA-6 mRNA and protein continue to be abundantly present. In a human adrenocortical cell line NCI-H295R, GATA-6 mRNA is up-regulated by cAMP. This cell line does not express GATA-4. Our findings suggest that GATA-6 expression is hormonally controlled, and required throughout adrenal development from fetal to adult age. GATA-4, on the other hand, may serve a role in fetal adrenal gene regulation.
UR - http://www.scopus.com/inward/record.url?scp=12244259069&partnerID=8YFLogxK
U2 - 10.1081/ERC-120016980
DO - 10.1081/ERC-120016980
M3 - Article
C2 - 12530677
AN - SCOPUS:12244259069
SN - 0743-5800
VL - 28
SP - 647
EP - 650
JO - Endocrine Research
JF - Endocrine Research
IS - 4
ER -