@article{c485c60eb53c4e97b5be15d455901623,
title = "Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate",
abstract = "Dendritic cells (DCs) and monocytes develop from a series of bone-marrow-resident progenitors in which lineage potential is regulated by distinct transcription factors. Zeb2 is an E-box-binding protein associated with epithelial-mesenchymal transition and is widely expressed among hematopoietic lineages. Previously, we observed that Zeb2 expression is differentially regulated in progenitors committed to classical DC (cDC) subsets in vivo. Using systems for inducible gene deletion, we uncover a requirement for Zeb2 in the development of Ly-6Chi monocytes but not neutrophils, and we show a corresponding requirement for Zeb2 in expression of the M-CSF receptor in the bone marrow. In addition, we confirm a requirement for Zeb2 in development of plasmacytoid DCs but find that Zeb2 is not required for cDC2 development. Instead, Zeb2 may act to repress cDC1 progenitor specification in the context of inflammatory signals.",
keywords = "Monocyte, Plasmacytoid dendritic cell, Transcription factor",
author = "Xiaodi Wu and Brise{\~n}o, {Carlos G.} and Grajales-Reyes, {Gary E.} and Malay Haldar and Arifumi Iwata and Kretzer, {Nicole M.} and Wumesh, {K. C.} and Roxane Tussiwand and Yujiro Higashi and Murphy, {Theresa L.} and Murphy, {Kenneth M.}",
note = "Funding Information: We thank J. Michael White and the technical staff of the Transgenic Knockout Micro-Injection Core in the Department of Pathology and Immunology at Washington University School of Medicine for mouse rederivation and the Genome Technology Access Center in the Department of Genetics at Washington University School of Medicine. The Genome Technology Access Center is partially supported by National Cancer Institute Cancer Center Support Grant P30 CA91842 to the Siteman Cancer Center and by Institute of Clinical and Translational Sciences/Clinical and Translational Science Award Grant UL1 TR000448 from the National Center for Research Resources, a component of the NIH, and by NIH Roadmap for Medical Research. This work was supported by the Howard Hughes Medical Institute (K.M.M.), NIH Grants 1K08AI106953 (to M.H.) and 1F31CA189491-01 (to G.E.G.-R.), American Heart Association Grant 12PRE12050419 (to W.K.), and the Burroughs Wellcome Fund Career Award for Medical Scientists (to M.H.). Publisher Copyright: {\textcopyright} 2016, National Academy of Sciences. All rights reserved.",
year = "2016",
month = dec,
day = "20",
doi = "10.1073/pnas.1611408114",
language = "English",
volume = "113",
pages = "14775--14780",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "51",
}