Transcription factor networks in dendritic cell development

Ansuman T. Satpathy, Kenneth M. Murphy, K. C. Wumesh

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Dendritic cells (DCs) are a heterogeneous population within the mononuclear phagocyte system (MPS) that derive from bone marrow precursors. Commitment and specification of hematopoietic progenitors to the DC lineage is critical for the proper induction of both immunity and tolerance. This review summarizes the important cytokines and transcription factors required for differentiation of the DC lineage as well as further diversification into specific DC subsets. We highlight recent advances in the characterization of immediate DC precursors arising from the common myeloid progenitor (CMP). Particular emphasis is placed on the corresponding temporal expression of relevant factors involved in regulating developmental options.

Original languageEnglish
Pages (from-to)388-397
Number of pages10
JournalSeminars in immunology
Volume23
Issue number5
DOIs
StatePublished - Oct 1 2011

Keywords

  • Common dendritic progenitor
  • Dendritic cell
  • Flt3-ligand
  • Lineage commitment
  • Transcription factor

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